Anthelmintic composition
A formulation having triclabendazole in solution. In addition a further anthelmintic may be included. The formulation is made by mixing the abamectin and benzyl alcohol and mixing this with triclabendazole and butyl dioxitol. The mix is then heated to dissolve the active, and allowed to cool at which stage the solution is diluted to volume with PEG 4000.
1. A pour-on formulation comprising a solution of about 30% w/v triclabendazole or its pharmaceutically acceptable salt thereof substantially dissolved in a solvent system;
about 0.5% w/v abamectin; and
wherein the solvent system comprises butyl dioxitol; benzyl alcohol; and polyethylene glycol 400.
2. The pour-on formulation according to claim 1 , wherein the butyl dioxitol, benzyl alcohol, and polyethylene glycol 400 are in an amount of about 50% w/v; about 5% w/v; and about 14.5% w/v, respectively.
3. A pour-on formulation comprising a solution of at least 20% w/v triclabendazole or its pharmaceutically acceptable salt substantially dissolved in a solvent system, about 0.5% w/v of milbemycin, and wherein the solvent system comprises butyl dioxitol, benzyl alcohol and polyethylene glycol 400.
4. A pour-on formulation comprising triclabendazole in an amount of about 30% w/v or its pharmaceutically acceptable salt substantially dissolved in a solvent system about 0.5% w/v of milbemycin, and wherein the solvent system comprises butyl dioxitol, benzyl alcohol and polyethylene glycol 400.
5. A pour-on formulation comprising a solution of at least 20% w/v triclabendazole or its pharmaceutically acceptable salt substantially dissolved in a solvent system, about 0.5% w/v of abamectin, and wherein the solvent system comprises butyl dioxitol, benzyl alcohol and polyethylene gycol 400.
6. A method of treating parasites in warm-blooded animals comprising administering to said animal in need thereof an effective amount of a pour-on formulation according to any one of claims 1 , 2 , 3 or 5 .
7. A method of treating liver flukes in warm-blooded animals comprising administering to said animal in need thereof an effective amount of a pour-on formulation according to any one of claims 1 , 2 , 3 or 5 .
8. A method of treating fasciolosis in warm-blooded animals comprising administering to said animal in need thereof an effective amount of a pour-on formulation according to any one of claims 1 , 2 , 3 or 5 .
9. The method according to claim 6 wherein said pour-on formulation is administered in a quantity of up to about 50 ml onto the skin surface of said animal.
10. The method according to claim 6 wherein said warm-blooded animal is a ruminant.
11. The method according to claim 7 wherein said pour-on formulation is administered in a quantity of up to about 50 ml onto the skin surface of said animal.
12. The method according to claim 7 wherein said warm-blooded animal is a ruminant.
13. The method according to claim 8 wherein said pour-on formulation is administered in a quantity of up to about 50 ml onto the skin surface of said animal.
14. The method according to claim 8 wherein said warm-blooded animal is a ruminant.
15. A pour-on formulation comprising a solution of about 10-40% w/v triclabendazole or its pharmaceutically acceptable salt thereof substantially dissolved in a solvent system;
about 0.5% w/v abamectin; and
wherein the solvent system comprises a glycol ether and benzyl alcohol.
16. A pour-on formulation comprising a solution of at least 10% w/v triclabendazole or its pharmaceutically acceptable salt substantially dissolved in a solvent system,
about 0.5% w/v of milbemycin, and
wherein the solvent system comprises a glycol ether and benzyl alcohol.
17. A pour-on formulation comprising a solution of at least 10% w/v triclabendazole or its pharmaceutically acceptable salt substantially dissolved in a solvent system,
about 0.5% w/v of abamectin, and
wherein the solvent system comprises a glycol ether and benzyl alcohol.
18. The pour-on formulation according to claim 16 or 17 , wherein the triclabendazole is present in an amount of about 30% w/v.
19. A method of treating parasites in warm-blooded animals comprising administering to said animal in need thereof an effective amount of a pour-on formulation according to of claim 16 or 17 .
20. A method of treating liver flukes in warm-blooded animals comprising administering to said animal in need thereof an effective amount of a pour-on formulation according to claim 16 or 17 .
21. A method of treating fasciolosis in warm-blooded animals comprising administering to said animal in need thereof an effective amount of a pour-on formulation according to claim 16 or 17 .
22. The method according to claim 20 wherein said pour-on formulation is administered in a quantity of up to about 50 ml onto the skin surface of said animal.
23. The method according to claim 20 wherein said warm-blooded animal is a ruminant.
24. The method according to claim 21 wherein said pour-on formulation is administered in a quantity of up to about 50 ml onto the skin surface of said animal.
25. The method according to claim 21 wherein said warm-blooded animal is a ruminant.
26. The method according to claim 20 wherein said pour-on formulation is administered in a quantity of up to about 50 ml onto the skin surface of said animal.
27. The method according to claim 20 wherein said warm-blooded animal is a ruminant.