Gonadotrophins in the treatment anovulatory women
View Patent ↗The present invention relates to the use of gonadotrophins in the induction of folliculogenesis in anovulatory women. In particular, if relates to the use of LH (or an equivalent dosage of hCG) in the production of a medicament for inducing folliculogenesis in anovulatory women at a specified daily doses. In certain embodiments. LH may be used in conjunction with FSH.
1. A method for inducing paucifolliculogenesis or unifolliculogenesis in WHO group II anovulatory women, comprising administering to WHO group II anovulatory women as an active agent LH at a daily dose in the range of 100 to 1500 IU, or an equivalent daily dose of hCG, starting in the mid- to late-follicular phase to induce paucifolliculogenesis or unifolliculogenesis, wherein the administration is to be started when there is at least one follicle having a mean diameter in a range of 11 to 14 mm and wherein the administration of FSH has been discontinued.
2. The method of claim 1 , comprising administering to WHO group II anovulatory women as an active agent hCG at a daily dose equivalent to a daily dose of LH in the range of 100 to 1500 IU, starting in the mid- to late-follicular phase to induce paucifolliculogenesis or unifolliculogenesis, wherein the equivalent dose of hCG is calculated as 1 IU of hCG being equivalent to 5-7 IU of LH.