Aromatic compositions for the inhibition of exoprotein production from gram positive bacteria
View Patent ↗Compositions including an aromatic compound for inhibiting the production of exoproteins by Gram positive bacteria are disclosed. The aromatic inhibitory compounds of the present invention have the general formula: wherein R 1 is selected from the group consisting of H, —OR 5 , —R 6 C(O)H, —R 6 OH, —R 6 COOH, —OR 6 OH, —OR 6 COOH, —C(O)NH 2 , and NH 2 and salts thereof; R 5 is a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety; R 6 is a divalent saturated or unsaturated aliphatic hydrocarbyl moiety; R 7 is a trivalent saturated or unsaturated aliphatic hydrocarbyl moiety; R 8 is a monovalent substituted or unsubstituted saturated or unsaturated aliphatic hydrocarbyl moiety which may or may not be interrupted with hetero atoms; R 2 , R 3 , and R 4 are independently selected from the group consisting of H, OH, COOH, and —C(O)R 9 ; R 9 is hydrogen or a monovalent saturated or unsaturated aliphatic hydrocarbyl moiety.
1. A douche formulation for inhibiting production of exoprotein from Gram positive bacteria comprising a vaginal cleansing formulation comprising a pharmaceutically acceptable carrier and from about 0.2 millimoles/liter to about 50 millimoles/liter of benzyl alcohol, wherein the benzyl alcohol is effective in inhibiting the production of exoprotein from Gram positive bacteria, and wherein the vaginal cleansing formulation is for use in a vagina.
2. The douche formulation as set forth in claim 1 , wherein the benzyl alcohol is effective in substantially inihibiting the production of Toxic Shock Syndrome Toxin-1 (TSST-1 from Staphylococcus aureus bacteria.
3. The douche formulation as set forth in claim 1 , wherein the benzyl alcohol is effective in substantially inhibiting the production of Enterotoxin B and alpha hemolysin from Staphylococcus aureus bacteria.
4. The douche formulation as set forth in claim 1 , wherein the benzyl alcohol is present in the vaginal cleansing formulation in an amount of from about 0.3 millimoles/liter to about 30 millimoles/liter.
5. The douche formulation as set forth in claim 1 , wherein the benzyl alcohol is present in the vaginal cleansing formulation in an amount of from about 1 millimoles/liter to about 15 millimoles/liter.