IP Library › Granted Patent US 7,053,190
Granted Patent B2
US 7,053,190 · App. 09/981,876 · Granted May 30, 2006

Secreted protein HRGDF73

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Quick Facts
Patent No.
US 7,053,190
App. No.
09/981,876
Granted
May 30, 2006
Kind
B2
Abstract

The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

Claims (46)

1. An isolated antibody or portion thereof that specifically binds to a protein whose sequence consists of amino acid residues 25 to 123 of SEQ ID NO:200.

2. The isolated antibody or portion thereof of claim 1 , wherein said protein specifically bound by said antibody or portion thereof is glycosylated.

3. The isolated antibody or portion thereof of claim 1 wherein the antibody is a monoclonal antibody.

4. The isolated antibody or portion thereof of claim 1 wherein the antibody is a polyclonal antibody.

5. The isolated antibody or portion thereof of claim 1 wherein the antibody is a chimeric antibody.

6. The isolated antibody or portion thereof of claim 1 wherein the antibody is a humanized antibody.

7. The isolated antibody or portion thereof of claim 1 wherein the antibody is a human antibody.

8. The isolated antibody or portion thereof of claim 1 wherein the portion thereof is a single chain antibody.

9. The isolated antibody or portion thereof of claim 1 wherein the portion thereof is a Fab fragment.

10. A labeled isolated antibody or portion thereof wherein the antibody or portion thereof of claim 1 is labeled.

11. The labeled isolated antibody or portion thereof of claim 10 , wherein the label is selected from the group consisting of:

(a) an enzyme label;

(b) a radioisotope label; and

(c) a fluorescent label.

12. An isolated cell that produces the isolated antibody of claim 1 .

13. A hybridoma that produces the isolated antibody of claim 1 .

14. A hybridoma that produces the isolated antibody of claim 3 .

15. An isolated antibody produced by immunizing an animal with a protein whose sequence consists of amino acid residues 25 to 123 of SEQ ID NO:200, wherein said antibody specifically binds to the protein of SEQ ID NO:200.

16. The isolated antibody of claim 15 , wherein said protein specifically bound by said antibody is glycosylated.

17. The isolated antibody of claim 15 wherein the antibody is a monoclonal antibody.

18. The isolated antibody of claim 15 wherein the antibody is a polyclonal antibody.

19. A labeled isolated antibody wherein the antibody of claim 15 is labeled.

20. The labeled isolated antibody of claim 19 , wherein the label is selected from the group consisting of:

(a) an enzyme label;

(b) a radioisotope label; and

(c) a fluorescent label.

21. An isolated cell that produces the isolated antibody of claim 15 .

22. A hybridoma that produces the isolated antibody of claim 15 .

23. A hybridoma that produces the isolated antibody of claim 17 .

24. An isolated antibody or portion thereof that specifically binds to a protein whose sequence consists of amino acid residues 1 to 123 of SEQ ID NO:200.

25. The isolated antibody or portion thereof of claim 24 , wherein said protein specifically bound by said antibody or portion thereof is glycosylated.

26. The isolated antibody or portion thereof of claim 24 wherein the antibody is a monoclonal antibody.

27. The isolated antibody or portion thereof of claim 24 wherein the antibody is a polyclonal antibody.

28. The isolated antibody or portion thereof of claim 24 wherein the antibody is a chimeric antibody.

29. The isolated antibody or portion thereof of claim 24 wherein the antibody is a humanized antibody.

30. The isolated antibody or portion thereof of claim 24 wherein the antibody is a human antibody.

31. The isolated antibody or portion thereof of claim 24 wherein the portion thereof is a single chain antibody.

32. The isolated antibody or portion thereof of claim 24 wherein the portion thereof is a Fab fragment.

33. A labeled isolated antibody or portion thereof wherein the antibody or portion thereof of claim 24 is labeled.

34. The labeled isolated antibody or portion thereof of claim 33 , wherein the label is selected from the group consisting of:

(a) an enzyme label;

(b) a radioisotope label; and

(c) a fluorescent label.

35. An isolated cell that produces the isolated antibody of claim 24 .

36. A hybridoma that produces the isolated antibody of claim 24 .

37. A hybridoma that produces the isolated antibody of claim 26 .