IP Library › Granted Patent US 7,060,812
Granted Patent B2
US 7,060,812 · App. 09/989,724 · Granted Jun 13, 2006

PRO1312 nucleic acids

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 7,060,812
App. No.
09/989,724
Granted
Jun 13, 2006
Kind
B2
Abstract

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Claims (21)

1. An isolated nucleic acid comprising:

(a) a nucleic acid sequence encoding the polypeptide of SEQ ID NO: 387;

(b) a nucleic acid sequence encoding the polypeptide of SEQ ID NO: 387, lacking its associated signal peptide;

(c) the nucleic acid sequence of SEQ ID NO: 386;

(d) the full-length coding sequence of the nucleic acid sequence of SEQ ID NO: 386; or

(e) the full-length coding sequence of the cDNA deposited under ATCC accession number 203132.

2. The isolated nucleic acid of claim 1 comprising a nucleic acid sequence encoding the polypeptide of SEQ ID NO: 387.

3. The isolated nucleic acid of claim 1 comprising a nucleic acid sequence encoding the polypeptide of SEQ ID NO: 387, lacking its associated signal peptide.

4. The isolated nucleic acid of claim 1 comprising the nucleic acid sequence of SEQ ID NO: 386.

5. The isolated nucleic acid of claim 1 comprising the full-length coding sequence of the nucleic acid sequence of SEQ ID NO: 386.

6. The isolated nucleic acid of claim 1 comprising the full-length coding sequence of the cDNA deposited under ATCC accession number 203132.

7. An isolated nucleic acid encoding a polypeptide having at least 99% sequence identity to:

(a) the amino acid sequence of the polypeptide of SEQ iD NO: 387;

(b) the amino acid sequence of the polypeptide of SEQ ID NO: 387, lacking its associated signal peptide;

(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the nucleic acid sequence of SEQ ID NO: 386; or

(d) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203132;

wherein said encoded polypeptide induces chondrocyte redifferentiation.

8. A vector comprising the nucleic acid of claim 7 or 1 .

9. The vector of claim 8 , wherein said nucleic acid is operably linked to control sequences recognized by a host cell transformed with the vector.

10. An isolated host cell comprising the vector of claim 8 .

11. The host cell of claim 10 , wherein said cell is a CHO cell, an E. coli or a yeast cell.