Topical product formulations containing strontium for reducing skin irritation
View Patent ↗Topical formulations containing aqueous-soluble divalent strontium cation in a suitable topical formulation vehicle, and methods of using these formulations to inhibit skin irritation, are disclosed.
1. A topical formulation for reducing skin irritation in animals comprising:
a salt comprising aqueous-soluble divalent strontium cation in an amount of about 0.5% by weight to about 14% by weight of the total formulation,
an irritant ingredient comprising an α-hydroxy acid, and
a suitable topical formulation vehicle.
2. The formulation of claim 1 wherein the formulation is an aqueous liquid.
3. The formulation of claim 1 wherein the formulation is a cream, lotion or gel.
4. The formulation of claim 1 wherein the formulation is a solid.
5. The formulation of claim 2 wherein the formulation vehicle comprises water and an organic solvent.
6. The formulation of claim 5 wherein the organic solvent is an alcohol.
7. The formulation of claim 2 wherein the formulation vehicle comprises a surfactant.
8. The formulation of claim 7 wherein the surfactant comprises a nonionic surfactant.
9. The formulation of claim 7 wherein the surfactant comprises a cationic surfactant.
10. The formulation of claim 7 wherein the surfactant comprises an amphoteric surfactant.
11. The formulation of claim 7 wherein the surfactant comprises at least one anionic surfactant and at least one amphoteric surfactant.
12. The formulation of claim 11 wherein the anionic surfactant comprises at least one surfactant selected from the group consisting of ammonium laureth sulfate, TEA laureth sulfate, sodium lauryl sulfosuccinate, sodium lauryl sarcosinate, and sodium laureth sulfate.
13. The formulation of claim 11 wherein the amphoteric surfactant comprises oleyl betaine or cocamidopropyl betaine.
14. The formulation of claim 7 wherein the surfactant comprises at least one nonionic and at least one cationic surfactant.
15. The formulation of claim 14 wherein the nonionic surfactant comprises at least one surfactant selected from the group consisting of Polysorbate 20, Polysorbate 40, Polysorbate 60, and Polysorbate 80.
16. The formulation of claim 14 wherein the cationic surfactant comprises cocamidopropyl phosphatidyl PG-dimonium chloride.
17. The formulation of claim 2 wherein the formulation vehicle further comprises at least one ingredient selected from the group consisting of viscosity adjusting agents, emollients, and moisturizers.
18. The formulation of claim 2 wherein the formulation vehicle comprises water and at least one ingredient selected from the group consisting of preservatives, fragrances, dyes, pigments, and colorants.
19. The formulation of claim 1 , wherein the formulation comprises an active ingredient.
20. The formulation of claim 19 wherein the active ingredient is selected from the group consisting of antibiotic, local anesthetic, sunscreen, retinoid, antiperspirant, antihistamine, analgesic, contraceptive, anti-acne and anti-dandruff ingredients.
21. The formulation of claim 3 wherein the formulation vehicle comprises a surfactant.
22. The formulation of claim 21 wherein the surfactant comprises a nonionic surfactant.
23. The formulation of claim 21 wherein the surfactant comprises a cationic surfactant.
24. The formulation of claim 21 wherein the surfactant comprises an amphoteric surfactant.
25. The formulation of claim 21 wherein the surfactant comprises at least one anionic surfactant and at least one amphoteric surfactant.
26. The formulation of claim 25 wherein the anionic surfactant comprises comprises at least one surfactant selected from the group consisting of ammonium laureth sulfate, TEA laureth sulfate, sodium lauryl sulfosuccinate, sodium lauryl sarcosinate, and sodium laureth sulfate.
27. The formulation of claim 25 wherein the amphoteric surfactant comprises oleyl betaine or cocamidopropyl betaine.
28. The formulation of claim 3 wherein the formulation vehicle comprises at least one ingredient selected from the group consisting of viscosity adjusting agents, emollients, and moisturizers.
29. The formulation of claim 3 wherein the formulation vehicle comprises at least one ingredient selected from the group consisting of preservatives, fragrances, dyes, pigments, and colorants.
30. The formulation of claim 19 wherein the active ingredient is selected from the group consisting of antibiotic, local anesthetic, sunscreen, retinoid, antiperspirant, antihistamine, analgesic, contraceptive, anti-acne and anti-dandruff ingredients.
31. The formulation of claim 1 , further comprising an irritant ingredient selected from the group consisting of carboxylic acids, keto acids, α-hydroxy acids, β-hydroxy acids, retinoids, peroxides, and organic alcohols.
32. The formulation of claim 1 wherein the α-hydroxy acid comprises at least one acid selected from lactic acid, glycolic acid, citric acid, and salts thereof.
33. The formulation of claim 31 wherein the irritant ingredient is a retinoid selected from tretinoin, retinol, retinal and derivatives thereof.
34. The formulation of claim 3 wherein the formulation vehicle comprises an emulsifier.
35. The formulation of claim 34 wherein the emulsifier comprises a nonionic emulsifier.
36. The formulation of claim 34 wherein the emulsifier comprises a cationic emulsifier.
37. The formulation of claim 34 wherein the emulsifier comprises at least one nonionic emulsifier and at least one cationic emulsifier.
38. The formulation of claim 4 wherein the formulation vehicle comprises a surfactant.
39. The formulation of claim 38 wherein the surfactant comprises a nonionic surfactant.
40. The formulation of claim 38 wherein the surfactant comprises a cationic surfactant.
41. The formulation of claim 38 wherein the surfactant comprises an amphoteric surfactant.
42. The formulation of claim 38 wherein the surfactant comprises at least one anionic surfactant and at least one amphoteric surfactant.
43. The formulation of claim 42 wherein the anionic surfactant comprises comprises at least one surfactant selected from the group consisting of ammonium laureth sulfate, TEA laureth sulfate, sodium lauryl sulfosuccinate, sodium lauryl sarcosinate, and sodium laureth sulfate.
44. The formulation of claim 42 wherein the amphoteric surfactant comprises oleyl betaine or cocamidopropyl betaine.
45. The formulation of claim 4 wherein the formulation vehicle comprises at least one ingredient selected from the group consisting of viscosity adjusting agents, emollients and moisturizers.
46. The formulation of claim 4 wherein the formulation vehicle comprises at least one ingredient selected from the group consisting of preservatives, fragrances, dyes, pigments, and colorants.
47. The formulation of claim 19 wherein the active ingredient is selected from the group consisting of antibiotic, local anesthetic, sunscreen, retinoid, antiperspirant, antihistamine, analgesic, contraceptive, anti-acne and anti-dandruff ingredients.
48. The formulation of claim 4 wherein the formulation vehicle comprises an emulsifier.
49. The formulation of claim 48 wherein the emulsifier comprises a nonionic emulsifier.
50. The formulation of claim 48 wherein the emulsifier comprises a cationic emulsifier.
51. The formulation of claim 48 wherein the emulsifier comprises at least one nonionic emulsifier and at least one cationic emulsifier.
52. A depilatory formulation comprising:
a depilatory agent; and
a skin irritation reducing salt comprising aqueous-soluble divalent strontium cation.
53. The depilatory formulation of claim 52 , wherein the depilatory agent is non-strontium.
54. The depilatory formulation of claim 52 , wherein the salt comprises one or more acidic anion species.
55. The depilatory formulation of claim 54 , wherein the acidic acidic anion species are selected from chloride, nitrate, and acetate.
56. The depilatory formulation of claim 52 , wherein the salt is selected from strontium chloride, strontium nitrate, and strontium acetate.
57. The depilatory formulation of claim 52 , wherein the salt comprises a halogen anion.
58. A composition for effective removal of hair with reduced skin irritation, the composition comprising:
a non-strontium active agent for removal of hair; and
a skin irritation reducing salt comprising aqueous-soluble strontium cation.
59. The formulation of claim 1 , wherein the formulation comprises a non-strontium active ingredient.
60. A topical formulation for reducing skin irritation in animals comprising:
a salt comprising aqueous-soluble divalent strontium cation in an amount of about 0.5% by weight to about 14% by weight of the total formulation;,
an irritant ingredient;
a suitable topical formulation vehicle; and
an active ingredient selected from the group local anesthetic, sunscreen, retinoid, antiperspirant, antihistamine, analgesic, contraceptive, anti-acne and anti-dandruff ingredients.