Method for the treatment of inflammatory disorders
View Patent ↗A method for the treatment of inflammatory disorders is disclosed, particularly the treatment of arthritis. The method comprises the administration of a function blocking antibody which is capable of binding an epitope of VLA-1.
1. A method for the treatment of arthritis comprising administering to a subject suffering from arthritis a composition comprising a function blocking antibody or a fragment of said antibody, wherein said antibody or fragment of said antibody is capable of binding an epitope of VLA-1, and wherein the epitope consists of the amino acids Val-Gln-Arg-Gly-Gly-Arg (SEQ ID NO:8), to provide a decrease in arthritic score of about 65% or greater when compared to a control antibody treated subject.
2. A method according to claim 1 wherein the decrease in arthritic score is about 79% or greater.
3. A method according to claim 1 wherein the decrease in arthritic score is about 85% or greater.
4. A method according to claim 1 wherein the decrease in arthritic score is about 90% or greater.
5. A method according to claim 1 , wherein the antibody is monoclonal.
6. A method according to claim 1 , wherein the subject is a human.
7. A method according to claim 1 , wherein the subject suffers from rheumatoid arthritis.