Secreted and transmembrane polypeptides and nucleic acids encoding the same
View Patent ↗The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
1. An isolated polypeptide having at least 80% amino acid sequence idefitity to:
(a) the amino acid sequence of the polypeptide of SEQ ID NO:180;
(b) the amino acid sequence of the polypeptide of SEQ ID NO:180, lacking its associated signal peptide;
(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203219;
wherein said polypeptide has fetal hemoglobin inducing activity.
2. The isolated polypeptide of claim 1 having at least 85% amino acid sequence identity to:
(a) the amino acid sequence of the polypeptide of SEQ ID NO:180;
(b) the amino acid sequence of the polypeptide of SEQ ID NO:180, lacking its associated signal peptide;
(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203219;
wherein said polypeptide has fetal hemoglobin inducing activity.
3. The isolated polypeptide of claim 1 having at least 90% amino acid sequence identity to:
(a) the amino acid sequence of the polypeptide of SEQ ID NO:180;
(b) the amino acid sequence of the polypeptide of SEQ ID NO:180, lacking its associated signal peptide;
(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203219;
wherein said polypeptide has fetal hemoglobin inducing activity.
4. The isolated polypeptide of claim 1 having at least 95% amino acid sequence identity to:
(a) the amino acid sequence of the polypeptide of SEQ ID NO:180;
(b) the amino acid sequence of the polypeptide of SEQ ID NO:180, lacking its associated signal peptide:
(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203219;
wherein said polypeptide has fetal hemoglobin inducing activity.
5. The isolated polypeptide of claim 1 having at least 99% amino acid sequence identity to:
(a) the amino acid sequence of the polypeptide of SEQ ID NO:180;
(b) the amino acid sequence of the polypeptide of SEQ ID NO:180, lacking its associated signal polypeptide;
(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203219;
wherein said polypeptide has fetal hemoglobin inducing activity.
6. An isolated polypeptide comprising:
(a) the amino acid sequence of the polypeptide of SEQ ID NO:180;
(b) the amino acid sequence of the polypeptide of SEQ ID NO:180, lacking its associated signal polypeptide;
(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203219.
7. The isolated polypeptide of claim 6 comprising the amino acid sequence of the polypeptide of SEQ ID NO:180.
8. The isolated polypeptide of claim 6 comprising the amino acid sequence of the polypeptide of SEQ ID NO:180, lacking its associated signal peptide.
9. The isolated polypeptide of claim 6 comprising the amino acid sequence of the polypeptide encoded by the full-length coding sequence ofthe cDNA deposited under ATCC accession number 203219.
10. A chimeric polypeptide comprising a polypeptide according to claim 1 fused to a heterologous polypeptide.
11. The chimeric polypeptide of claim 10 , wherein said heterologous polypeptide is an epitope tag or an Fc region of an immunoglobulin.