Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof

1. An aminophenoxyacetamide derivative represented by the following formula (I):

wherein:

R 1 , R 2 , R 3 and R 4 are, independent from each other, hydrogen atom or lower alkyl group;

R 5 R 6 R 7 and R 8 are, independent from each other, hydrogen atom or lower alkyl group;

E 1 is group —NR 9 — (in which, R 9 is hydrogen atom or lower alkyl group);

E 2 is oxygen atom or group —NR 10 — (in which, R 10 is hydrogen atom or lower alkyl group which may be substituted);

Q is a group of —X—Y-Q′, wherein X is a connecting bond, lower alkyl group, lower alkenyl group, or lower alkenyl group; Y is a connecting bond, or a group selected from the groups consisting of C═O, C(═O)NH, NHC(═O), —O—, —S—, CH(OH), —O—CH(OH)— and —O—CH 2 —CH(OH)—, in which hydrogen atom of amido group may be substituted with lower alkyl group; and Q′ is hydrogen atom or a cyclic group selected from the group consisting of phenyl group, pyridily group, quinolyl group, isoquinolyl group, benzothiazole group, benzimidazole group, morpholinyl group, and cyclic hydrocarbon group, wherein one or more of the hydrogen atoms in the cyclic group of Q′ may be substituted;

either in the case that E 2 is the group —NR 10 — then X and Y are both connecting bond and Q′ is not hydrogen atom; or in the case that E 2 is the group —O— then all of the groups R 1 , R 2 , R 3 and R 4 are methyl group; or a pharmaceutically acceptable salt thereof.

2. The aminophenoxyacetamide derivative of formula (I) claimed in claim 1 , wherein X and Y are both connecting bond; or pharmaceutically acceptable salts thereof.

3. The aminophenoxyacetamide derivative of formula (I) claimed in claim 1 , wherein one of X and Y is other than connecting bond and E 2 is the group —O— and all of the groups of R 1 , R 2 , R 3 and R 4 are other than hydrogen atom, wherein X, Y, R 1 , R 2 , R 3 and R 4 are the same as defined above in claim 1 ; or pharmaceutically acceptable salts thereof.

4. A composition comprising an aminophenoxyacetamide derivative or a pharmaceutically acceptable salt thereof represented by the formula (I) in claim 1 as an active ingredient.

5. A composition comprising an aminophenoxyacetamide derivative or a pharmaceutically acceptable salt thereof represented by the formula (I) in claim 2 as an active ingredient.

6. A composition comprising an aminophenoxyacetamide derivative or a pharmaceutically acceptable salt thereof represented by the formula (I) in claim 3 as an active ingredient.

7. An aminophenoxyacetamide derivative represented by the following formula (I):

wherein:

R 1 , R 2 , R 3 and R 4 are, independent from each other, hydrogen atom or lower alkyl group;

R 5 R 6 R 7 and R 8 are, independent from each other, hydrogen atom or lower alkyl group;

E 1 is group —NR 9 — (in which, R 9 is hydrogen atom or lower alkyl group);

E 2 is oxygen atom or group —NR 10 — (in which, R 10 is hydrogen atom or lower alkyl group which may be substituted);

Q is a group of —X—Y-Q′, wherein X is a connecting bond, lower alkyl group, lower alkenyl group, or lower alkenyl group; Y is a connecting bond, or a group selected from the groups consisting of C═O, C(═O)NH, NHC(═O), —O—, —S—, CH(OH), —O—CH(OH)— and —O—CH 2 —CH(OH)—, in which hydrogen atom of amido group may be substituted with lower alkyl group; and Q′ is hydrogen atom or a cyclic group selected from the group consisting of phenyl group, pyridily group, ciuinolyl group, isociuinolyl group, benzothiazole group, benzimidazole group, morpholinyl group, and cyclic hydrocarbon group, wherein one or more of the hydrogen atoms in the cyclic group of Q′ may be substituted;

either in the case that E 2 is the group —NR— then X and Y are both connecting bond and Q′ is not hydrogen atom; or in the case that E 2 is the group —O— then all of the groups R 1 , R 2 , R 3 and R 4 are methyl group; or a pharmaceutically acceptable salt thereof,

where Q′ is a cyclic hydrocarbon group and said cyclic hydrocarbon group is cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl.

8. An aminophenoxyacetamide derivative represented by the following formula (I):

wherein:

R 1 , R 2 , R 3 and R 4 are, independent from each other, hydrogen atom or lower alkyl group;

R 5 R 6 R 7 and R 8 are, independent from each other, hydrogen atom or lower alkyl group;

E 1 is group —NR 9 — (in which, R 9 is hydrogen atom or lower alkyl group); E 2 is oxygen atom or group —NR 10 — (in which, R 10 is hydrogen atom or lower alkyl group which may be substituted);

Q is a group of —X—Y-Q′, wherein X is a connecting bond, lower alkyl group, lower alkenyl group, or lower alkenyl group; Y is a connecting bond, or a group selected from the groups consisting of C═O, C(═O)NH, NHC(═O), —O—, —S—, CH(OH), —O—CH(OH)— and —O—CH 2 —CH(OH)—, in which hydrogen atom of amido group may be substituted with lower alkyl group; and Q′ is hydrogen atom or a cyclic group selected from the group consisting of phenyl group, pyridily group, ciuinolyl group, isociuinolyl group, benzothiazole group, benzimidazole group, morpholinyl group, and cyclic hydrocarbon group, wherein one or more of the hydrogen atoms in the cyclic group of Q′ may be substituted;

either in the case that E 2 is the group —NR 10 — then X and Y are both connecting bond and Q′ is not hydrogen atom; or in the case that E 2 is the group —O— then all of the groups R 1 R 2 , R 3 and R 4 are methyl group; or a pharmaceutically acceptable salt thereof, wherein Q′ is an unsaturated or saturated heterocyclic group and said unsaturated or saturated heterocyclic group is morpholinyl.