IP Library › Granted Patent US 7,012,131
Granted Patent B2
US 7,012,131 · App. 10/011,795 · Granted Mar 14, 2006

Pro1410 polypeptides

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Quick Facts
Patent No.
US 7,012,131
App. No.
10/011,795
Granted
Mar 14, 2006
Kind
B2
Abstract

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Claims (34)

1. An isolated polypeptide having at least 80% amino acid sequence identity to:

(a) the amino acid sequence of the polypeptide of SEQ ID NO:271;

(b) the amino acid sequence of the polypeptide of SEQ ID NO:271; lacking its associated signal peptide;

(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203277;

wherein said polypeptide induces chondrocyte proliferation.

2. The isolated polypeptide of claim 1 having at least 85% amino acid sequence identity to:

a) the amino acid sequence of the polypeptide of SEQ ID NO:271;

(b) the amino acid sequence of the polypeptide of SEQ ID NO:271; lacking its associated signal peptide;

(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203277;

wherein said polypeptide induces chondrocyte proliferation.

3. The isolated polypeptide of claim 1 having at least 90% amino acid sequence identity to:

(a) the amino acid sequence of the polypeptide of SEQ ID NO:271;

(b) the amino acid sequence of the polypeptide of SEQ ID NO:271; lacking its associated signal peptide;

(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203277;

wherein said polypeptide induces chondrocyte proliferation.

4. The isolated polypeptide of claim 1 having at least 95% amino acid sequence identity to:

(a) the amino acid sequence of the polypeptide of SEQ ID NO:271;

(b) the amino acid sequence of the polypeptide of SEQ ID NO:271; lacking its associated signal peptide;

(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203277;

wherein said polypeptide induces chondrocyte proliferation.

5. The isolated polypeptide of claim 1 having at least 99% amino acid sequence identity to:

(a) the amino acid sequence of the polypeptide of SEQ ID NO:271;

(b) the amino acid sequence of the polypeptide of SEQ ID NO:271; lacking its associated signal peptide;

(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203277;

wherein said polypeptide induces chondrocyte proliferation.

6. A chimeric polypeptide comprising a polypeptide according to claim 1 fused to a heterologous polypeptide.

7. The chimeric polypeptide of claim 6 , wherein said heterologous polypeptide is an epitope tag or an Fc region of an immunoglobulin.

8. An isolated polypeptide comprising:

(a) the amino acid sequence of the polypeptide of SEQ ID NO:271;

(b) the amino acid sequence of the polypeptide of SEQ ID NO:271, lacking its associated signal peptide;

(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203277.

9. The isolated polypeptide of claim 8 comprising the amino acid sequence of the polypeptide of SEQ ID NO:271.

10. The isolated polypeptide of claim 8 comprising the amino acid sequence of the polypeptide of SEQ ID NO:271, lacking its associated signal peptide.

11. The isolated polypeptide of claim 8 comprising the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203277.