IP Library › Granted Patent US 7,019,124
Granted Patent B2
US 7,019,124 · App. 10/013,929 · Granted Mar 28, 2006

PRO788 nucleic acids

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Quick Facts
Patent No.
US 7,019,124
App. No.
10/013,929
Granted
Mar 28, 2006
Kind
B2
Abstract

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Claims (45)

1. An isolated nucleic acid encoding a polypeptide having at least 80% sequence identity to:

(a) the amino acid sequence of the polypeptide of SEQ ID NO:454;

(b) the amino acid sequence of the polypeptide of SEQ ID NO:454, lacking its associated signal peptide;

(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the nucleic acid sequence of SEQ ID NO:453; or

(d) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 209849,

wherein the encoded polypeptide induces chondrocyte re-differentiation.

2. The isolated nucleic acid of claim 1 encoding a polypeptide having at least 85% sequence identity to:

(a) the amino acid sequence of the polypeptide of SEQ ID NO:454;

(b) the amino acid sequence of the polypeptide of SEQ ID NO:454 , lacking its associated signal peptide;

(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the nucleic acid sequence of SEQ ID NO:453 ; or

(d) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 209849,

wherein the encoded polypeptide induces chondrocyte re-differentiation.

3. The isolated nucleic acid of claim 1 encoding a polypeptide having at least 90% sequence identity to:

(a) the amino acid sequence of the polypeptide of SEQ ID NO:454;

(b) the amino acid sequence of the polypeptide of SEQ ID NO:454, lacking its associated signal peptide;

(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the nucleic acid sequence of SEQ ID NO:453; or

(d) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 209849,

wherein the encoded polypeptide induces chondrocyte re-differentiation.

4. The isolated nucleic acid of claim 1 encoding a polypeptide having at least 95% sequence identity to:

(a) the amino acid sequence of the polypeptide of SEQ ID NO:454;

(b) the amino acid sequence of the polypeptide of SEQ ID NO:454, lacking its associated signal peptide;

(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the nucleic acid sequence of SEQ ID NO:453; or

(d) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 209849,

wherein the encoded polypeptide induces chondrocyte re-differentiation.

5. The isolated nucleic acid of claim 1 encoding a polypeptide having at least 99% sequence identity to:

(a) the amino acid sequence of the polypeptide of SEQ ID NQ:454;

(b) the amino acid sequence of the polypeptide of SEQ ID NO:454, lacking its associated signal peptide;

(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the nucleic acid sequence of SEQ ID NO:453; or

(d) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 209849,

wherein the encoded polypeptide induces chondrocyte re-differentiation.

6. An isolated nucleic acid comprising:

(a) a nucleic acid sequence encoding the polypeptide of SEQ ID NO:454

(b) a nucleic acid sequence encoding the polypeptide of SEQ ID NO:454, lacking its associated signal peptide;

(c) the nucleic acid sequence of SEQ ID NO:453;

(d) the full-length coding sequence of the nucleic acid sequence of SEQ ID NO:453; or

(e) the full-length coding sequence of the cDNA deposited under ATCC accession number 209849.

7. The isolated nucleic acid of claim 6 comprising a nucleic acid sequence encoding the polypeptide of SEQ ID NO:454.

8. The isolated nucleic acid of claim 6 comprising a nucleic acid sequence encoding the polypeptide of SEQ ID NO:454, lacking its associated signal peptide.

9. The isolated nucleic acid of claim 6 comprising the nucleic acid sequence of SEQ ID NO:453.

10. The isolated nucleic acid of claim 6 comprising the full-length coding sequence of the nucleic acid sequence of SEQ ID NO:453.

11. The isolated nucleic acid of claim 6 comprising the full-length coding sequence of the cDNA deposited under ATCC accession number 209849.

12. A vector comprising the nucleic acid of claim 1 .

13. The vector of claim 12 , wherein said nucleic acid is operably linked to control sequences recognized by a host cell transformed with the vector.

14. An isolated host cell comprising the vector of claim 12 .

15. The host cell of claim 14 , wherein said cell is a CHO cell, an E. coli or a yeast cell.