Antibiotic agents
View Patent ↗Methods of treating a microbial infection comprising administering to a patient in need of such treatment are disclosed. In one aspect the method comprises administering to a patient in need of such treatment a therapeutically effective amount of Erythromycin B (or a pharmaceutically acceptable derivative thereof). In another aspect the method comprises a pharmaceutical composition comprising at least 50% by weight of Erythromycin B (or a pharmaceutically acceptable derivative thereof) of the total weight of antibiotic present in the composition. Also disclosed are 2′-esters of Erythromycin B and Erythromycin B enol ether.
1. A method of treating a bacterial infection comprising administering to a patient in need of such treatment a therapeutically effective amount of an antibiotic agent, wherein said antibiotic agent is a 2′ ester of Erythromycin B with a dicarboxylic acid or a 2′-carboxylic acid ester of Erythromycin B enol ether.
2. The method as claimed in claim 1 wherein the antibiotic agent is a 2′-ester of Erythromycin B enol ether with a monocarboxylic acid.
3. The method as claimed in claim 1 wherein the antibiotic agent is 2′-ester of Erythromycin B enol ether with a dicarboxylic acid.
4. The method as claimed in claim 3 wherein the ester is a succinate ester.
5. The method as claimed in claim 1 wherein the 2′ carboxylic acid ester of Erythromycin B is a succinate ester.
6. The method as claimed in claim 1 wherein the antibiotic agent is administered in an amount of up to 500 mg per day.
7. The method as claimed in claim 1 wherein the antibiotic agent is administered in an amount of 250 to 500 mg per day.
8. The method as claimed in claim 1 wherein the antibiotic agent is administered in the form of a tablet, a capsule, an elixir, an injectable or a syrup.
9. The method as claimed in claim 1 wherein the bacterial infection is TB, Syphilis, Helicobacter pylori or Chlamydia.
10. An antibiotic composition comprising a therapeutically effective amount of an antibiotic agent, wherein said antibiotic agent is a 2′ ester of Erythromycin B with a dicarboxylic acid or a 2′-carboxylic acid esters of Erythromycin B enol ether.
11. The composition as claimed in claim 10 wherein the antibiotic agent is a 2′-ester of Erythromycin B enol ether with a monocarboxylic acid.
12. The composition as claimed in claim 10 wherein the antibiotic agent is 2′-ester of Erythromycin B enol ether with a dicarboxylic acid.
13. The composition as claimed in claim 12 wherein the ester is a succinate ester.
14. The composition as claimed in claim 10 wherein the 2′ carboxylic acid ester of Erythromycin B is a succinate ester.
15. A 2′-carboxylic acid ester of Erythromycin B enol ether.
16. The ester as claimed in claim 15 which is a 2′-ester of Erythromycin B enol ether with a monocarboxylic acid.
17. The ester as claimed in claim 15 which is a 2′-ester of Erythromycin B enol ether with a dicarboxylic acid.
18. The ester as claimed in claim 17 wherein the ester is a succinate ester.
19. A 2′-ester of Erythromycin B with a dicarboxylic acid.
20. The ester as claimed in claim 19 which is a succinate ester.