Stabilization of antibodies or fragments thereof
View Patent ↗There is provided an antibody granule, consisting essentially of one or more antibodies, or fragments derived thereof, granulated with an alkali metal salt. Also provided is a process for preparing said antibody granules. The granules can be used in an enzymatic stain bleaching or anti dye-transfer composition.
1. A process for preparing an antibody granule consisting essentially of granulating one or more antibodies, or fragments derived thereof, with a solid alkali metal salt, and an acrylate/maleate copolymer binder, wherein the antibody granule contains more than 80 wt. % alkali metal salt.
2. The process according to claim 1 , wherein the alkali metal is sodium or potassium.
3. The process according to claim 1 , wherein the antibody has a chemical equilibrium constant K d for its antigen of less than 1*10 −4 .
4. The process according to claim 1 , wherein the antibody has a chemical equilibrium constant K d for its antigen of less than 1*10 −7 .
5. The process according to claim 1 , where in the granulating temperature is 30° C. or higher.
6. The process according to claim 1 , wherein the granulating pH is kept at a value from 6.0 to 10.0.
7. The process according to claim 1 , wherein the antibody granule contains more than 90 wt. % alkali metal salt.
8. The process according to claim 1 , wherein the antibody has a chemical equilibrium constant K d for its antigen of less than 1*10 −6 .
9. Process according to claim 1 , wherein the granulating temperature is from 30° C. to 80° C.
10. Process according to claim 1 , wherein the granulating pH is kept at a value from 7.0 to 9.0.