Methods for modulating tumor growth and metastasis
View Patent ↗Methods and pharmaceutical compositions for modulating tumor growth or metastasis are provided.
1. A method for modulating tumor growth or metastasis in an animal in need thereof, comprising sequential or simultaneous administration of paclitaxel and combretastatin A-4 phosphate prodrug salt in amounts effective therefor.
2. A method for modulating tumor growth or metastasis in an animal in need thereof, comprising administration of combretastatin A-4 phosphate prodrug salt and paclitaxel, in amounts effective therefor, wherein said combretastatin A-4 phosphate prodrug salt is administered at a time relative to administration of said paclitaxel sufficient to modulate blood flow to said tumor to provide a time-dependent effective tumor concentration of said paclitaxel.
3. The method as claimed in claim 1 or 2 , wherein said combretastatin A4 phosphate prodrug salt is administered at least 3 hours prior to paclitaxel.
4. A pharmaceutical composition for modulating tumor growth or metastasis in an animal in need thereof, comprising paclitaxel, and combretastatin A-4 phosphate prodrug salt, in amounts effective therefore in a pharmaceutically acceptable carrier.