Method for enhancing production performance in an animal
View Patent ↗The present invention provides methods for activating the immune systems of newborn animals and methods for enhancing the production performance of the animals. More particularly, the methods of the present invention involve the administration of compositions comprising mycrobacterial cell wall extract, most preferably cell wall extracts of Mycobacterium phlei.
1. A method, comprising administering to an animal between 1 hour and 28 days of age, an amount of a mycobacterial cell wall extract, wherein the amount is effective to activate the immune system of the animal,
wherein the mycobacterial cell wall extract contains oil.
2. The method of claim 1 , wherein the administration to the animal occurs between 1 hour and 4 days of age.
3. The method of claim 1 , wherein the administration to the animal occurs between 1 hour and 24 hours of age.
4. The method of claim 1 , wherein the mycobacterial cell wall extract is prepared from family Mycobacteriaceae, genus Mycobacterium , or species Mycobacterium phlei.
5. The method of claim 1 , wherein activation of the immune system comprises activation of white blood cells.
6. The method of claim 5 , wherein the white blood cells are group T-lymphocytes or monocytes.
7. The method of claim 6 , wherein the T-lymphocytes are CD4 + T lymphocytes.
8. The method of claim 7 , wherein the CD4 + T lymphocytes are CD25 + CD4 + T lymphocytes or MHC Class II + CD4 + T lymphocytes.
9. The method of claim 6 , wherein the monocytes are MHC Class II + monocytes.
10. The method of claim 5 , wherein the activated white blood cells display enhanced production of IFN-γ in response to a stimulus.
11. The method of claim 1 , wherein the animal is a mammal, bird, fish, amphibian or crustacean.
12. The method of claim 1 , wherein the animal is domestic food animal.
13. The method of claim 12 , wherein the domestic food animal is a calf, a chick, a piglet, a kid, a fawn or a lamb.
14. The method of claim 12 , wherein the domestic food animal is a calf of a domestic cow.
15. The method of claim 12 , wherein the domestic food animal is a chick of a domestic fowl.
16. The method of claim 1 , wherein the mycobacterial cell wall extract is combined with a pharmaceutically acceptable carrier.
17. The method of claim 1 , wherein the administration is subcutaneous, intravenous, intramuscular, intraperitoneal or oral.
18. The method of claim 1 , wherein the amount of the mycobacterial cell wall extract administered to the animal is from about 0.001 μg per kg to about 600 μg per kg per dose.
19. The method of claim 1 , wherein the amount of the mycobacterial cell wall extract administered to the animal is from about 0.01 μg per kg to about 400 μg per kg per dose.
20. The method of claim 1 , wherein the amount of the mycobacterial cell wall extract administered to the animal is from about 0.1 μg per kg to about 200 μg per kg per dose.
21. A method, comprising administering to an animal between 1 hour and 28 days of age, an amount of a mycobacterial cell wall extract, wherein the amount is effective to enhance production performance of the animal.
22. The method of claim 21 , wherein the administration to the animal occurs between 1 hour and 4 days of age.
23. The method of claim 21 , wherein the administration to the animal occurs between 1 hour and 24 hours of age.
24. The method of claim 21 , wherein the mycobacterial cell wall extract is prepared from family Mycobacteriaceae, genus Mycobacterium , or species Mycobacterium phlei.
25. The method of claim 21 , wherein the enhancement of production performance is an increase in the average daily weight gain of the animal or an increase in efficiency of feed use.
26. The method of claim 21 , wherein the enhancement of production performance is a decrease in the mortality of the animal, a decrease in the number of treatment days necessary to maintain the health of the animal, a decrease in the cost of treatment necessary to maintain the health of the animal, or any combination thereof.
27. The method of claim 21 , wherein the animal is a mammal, bird, fish, amphibian or crustacean.
28. The method of claim 21 , wherein the animal is domestic food animal.
29. The method of claim 28 , wherein the domestic food animal is a calf, a chick, a piglet, a kid, a fawn or a lamb.
30. The method of claim 28 , wherein the domestic food animal is a calf of a domestic cow.
31. The method of claim 28 , wherein the domestic food animal is a chick of a domestic fowl.
32. The method of claim 21 , wherein the mycobacterial cell wall extract is combined with a pharmaceutically acceptable carrier.
33. The method of claim 21 , wherein the administration is subcutaneous, intravenous, intramuscular, intraperitoneal or oral.
34. The method of claim 21 , wherein the amount of the mycobacterial cell wall extract administered to the animal is from about 0.001 μg per kg to about 600 μg per kg per dose.
35. The method of claim 21 , wherein the amount of the mycobacterial cell wall extract administered to the animal is from about 0.01 μg per kg to about 400 μg per kg per dose.
36. The method of claim 21 , wherein the amount of the mycobacterial cell wall extract administered to the animal is from about 0.1 μg per kg to about 200 μg per kg per dose.