Bicarbonate-based solutions for dialysis therapies
View Patent ↗Bicarbonate containing solutions for use during medical treatment are provided. The bicarbonate containing solution of the present invention includes at least two separate components including a bicarbonate concentrate and an electrolyte concentrate which can be readily and sterilely mixed to form a ready-to-use formulation for patient administration, particularly as applied to the treatment of acute renal failure associated with critically ill patients in an intensive care setting.
1. A two part dialysis solution comprising:
a bicarbonate concentrate; and
an electrolyte concentrate, wherein the bicarbonate concentrate and the electrolyte concentrate include a physiological amount of sodium ranging from 100 mmol/L to 173 mmol/L, and wherein the two part dialysis solution does not include acetate, wherein a mixed solution of the bicarbonate concentrate end the electrolyte concentrate further comprises about 0 mmol/L to about 2.0 mmol/L of calcium, about 0 mmol/L to about 1.5 mmol/L of magnesium, about 0 mmol/L to about 5 mmol/L of potassium, about 20 mmol/L to about 45 mmol/L of bicarbonate, about 70 mmol/L to about 130 mmol/L of chloride, about 0 mmol/L to about 45 mmol/L of lactate, and about 0 g/L to about 2.5 g/L of anhydrous glucose.
2. The two putt dialysis solution of claim 1 , wherein the bicarbonate concentrate is stored in a first chamber of a multi-chamber container and the electrolyte concentrate is stored in a second chamber of the multi-chamber container.
3. The two part dialysis solution of claim 1 , wherein the two part dialysis solution is a hemodialysis solution.
4. The two part dialysis solution of claim 1 , wherein the two part dialysis is a solution is a continuous renal replacement therapy solution.
5. The two part dialysis solution of claim 1 , wherein the two part dialysis solution is an infusion solution.
6. The two part dialysis solution of claim 1 , wherein the two part dialysis solution is a peritoneal dialysis solution.
7. A method of providing dialysis to a patient comprising:
providing a two part dialysis solution not including acetate, the two part dialysis solution comprising a bicarbonate concentrate and an electrolyte concentrate wherein the bicarbonate concentrate and the electrolyte concentrate include a physiological amount of sodium ranging from 100 mmol/L to 173 mmol/L;
mixing the bicarbonate concentrate and the electrolyte concentrate to form a mixed solution; and
using the mixed solution during dialysis, wherein the mixed solution further includes about 0 mmol/L to about 2.0 mmol/L of calcium, about 0 mmol/L to about 1.5 mmol/L of magnesium, about 0 mmol/L to about 5 mmol/L of potassium, about 20 mmol/L to about 45 mmol/L of bicarbonate, about 70 mmol/L to about 130 mmol/L of chloride, about 0 mmol/L to about 45 mmol/L of lactate, and about 0 g/L to about 2.5 g/L of anhydrous glucose.
8. The method of claim 7 , wherein the mixed solution is used during hemodialysis.
9. The method of claim 7 , wherein the mixed solution is used during continuous renal replacement therapy.
10. The method of claim 7 , wherein the mixed solution is infused into the patient as an infusion solution.
11. The method of claim 7 , wherein the mixed solution is used during peritoneal dialysis.