Devices and methods for cerebral perfusion augmentation
Methods are provided for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Methods include partial or complete obstruction of the femoral or iliac arteries or the inferior vena cava, external compression of the iliac, femoral, or brachial arteries, placing the patient in a trendelenberg position, applying one or more compression members to the extremities, or removing portion(s) of cerebral spinal fluid. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide additional therapeutic intervention.
1. A method for enhancing cerebral blood flow in a patient, comprising the steps of:
measuring a baseline cerebral blood flow;
inserting a first expandable member into at least one of a right femoral artery and/or a right iliac artery and expanding the first expandable member to at least partially obstruct the at least one right femoral artery and/or right iliac artery;
inserting a second expandable member into at least one of a left femoral artery and/or a left iliac artery and expanding the second expandable member to at least partially obstruct the at least one left femoral artery and/or left iliac artery;
measuring an enhanced cerebral blood flow after the at least partial obstruction of the right and left femoral artery and/or iliac artery; and
comparing the enhanced cerebral blood flow to the baseline cerebral blood flow.
2. The method of claim 1 , further comprising the step of adjusting the level of obstruction of the right femoral artery and/or the left femoral artery to achieve a desired increase in cerebral blood flow.
3. The method of claim 2 , wherein the desired increase in cerebral blood flow is 25 percent or more.
4. The method of claim 1 , further comprising the step of adjusting the level of obstruction of the right iliac artery and/or the left iliac artery to achieve a desired increase in cerebral blood flow.
5. The method of claim 1 , wherein the first and second expandable members are balloons.
6. The method of claim 1 , wherein at least one of the first and second expandable members is expanded to fully obstruct a least one of the right femoral artery and/or the right iliac artery.
7. The method of claim 1 , further comprising the step of measuring blood pressure in the femoral or iliac arteries using a manometer mounted distal to the expandable members.
8. The method of claim 1 , wherein the expandable members communicate with inflation lumens.