Bone graft substitute composition
View Patent ↗A bone graft substitute composition can include essentially of calcium sulfate, a mixing solution, and a plasticizing substance. A bone graft substitute composition can include calcium sulfate, demineralized bone matrix, cancellous bone, a plasticizing substance, and a mixing solution.
1. A bone graft substitute composition, comprising:
calcium sulfate;
demineralized bone matrix;
cancellous bone;
plasticizing substance; and
a mixing solution.
2. The composition of claim 1 , wherein the calcium sulfate comprises calcium sulfate hemihydrate.
3. The composition of claim 1 , wherein the plasticizing substance comprises a cellulose derivative.
4. The composition of claim 1 , wherein the plasticizing substance is selected from a group consisting of sodium carboxymethylcellulose, methylcellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, ethylcellulose, hydroxyethylcellulose, and cellulose acetate butyrate.
5. The composition of claim 1 , wherein the mixing solution is selected from a group consisting of sterile water, inorganic salt, and cationic surface active agent.
6. The composition of claim 5 , wherein the cationic surface active agent is selected from a group consisting of sodium chloride, phosphate buffered saline, potassium chloride, sodium sulfate, ammonium sulfate, ammonium acetate, and sodium acetate.
7. The composition of claim 1 , wherein the mixing solution comprises sterile water.
8. The composition of claim 1 , comprising:
about 80 to about 120 parts by weight of calcium sulfate;
about 10 to about 100 parts by weight of demineralized bone matrix;
about 10 to about 100 parts by weight of cancellous bone;
about 1 to about 40 parts by weight of a plasticizing substance; and
about 21 to about 250 parts by weight of a mixing solution.
9. The composition of claim 1 , comprising:
about 90 to about 110 parts by weight of calcium sulfate;
about 10 to about 50 parts by weight of demineralized bone matrix;
about 15 to about 50 parts by weight of cancellous bone;
about 5 to about 20 parts by weight of a plasticizing substance; and
about 80 to about 120 parts by weight of a mixing solution.
10. The composition of claim 1 , comprising:
about 98 to about 102 parts by weight of calcium sulfate;
about 13 to about 23 parts by weight of demineralized bone matrix;
about 27 to about 33 parts by weight of cancellous bone;
about 15 to about 20 parts by weight of a plasticizing substance; and
about 95 to about 105 parts by weight of a mixing solution.
11. The composition of claim 1 , comprising:
about 100 parts by weight of calcium sulfate;
about 18 to about 19 parts by weight of demineralized bone matrix;
about 27 to about 28 parts by weight of cancellous bone;
about 17 to about 18 parts by weight of a plasticizing substance; and
about 101 to about 102 parts by weight of a mixing solution.
12. A bone graft substitute composition, comprising:
about 80 to about 120 parts by weight of calcium sulfate hemihydrate;
about 10 to about 100 parts by weight of demineralized bone matrix;
about 10 to about 100 parts by weight of cancellous bone;
about 1 to about 40 parts by weight of a carboxymethylcellulose; and
about 21 to about 250 parts by weight of sterile water.
13. The composition of claim 12 , comprising:
about 90 to about 110 parts by weight of calcium sulfate hemihydrate;
about 10 to about 50 parts by weight of demineralized bone matrix;
about 15 to about 50 parts by weight of cancellous bone;
about 5 to about 20 parts by weight of carboxymethylcellulose; and
about 80 to about 120 parts by weight of sterile water.
14. The composition of claim 12 , comprising:
about 98 to about 102 parts by weight of calcium sulfate hydrate;
about 13 to about 23 parts by weight of demineralized bone matrix;
about 27 to about 33 parts by weight of cancellous bone;
about 15 to about 20 parts by weight of carboxymethylcellulose; and
about 95 to about 105 parts by weight of sterile water.
15. The composition of claim 12 , comprising:
about 100 parts by weight of calcium sulfate hemihydrate;
about 18 to about 19 parts by weight of demineralized bone matrix;
about 27 to about 28 parts by weight of cancellous bone;
about 17 to about 18 parts by weight of carboxymethylcellulose; and
about 101 to about 102 parts by weight of sterile water.