Water soluble and palatable complexes
View Patent ↗The products and methods of the present invention provide a means for increasing the solubility and bioavailability of active agents. More particularly the invention provides compositions containing active agents as water-soluble complexes with glycyrrhizin, and methods of preparing such complexes. The invention further provides methods for the preparation of highly water soluble complex dosage forms.
1. A composition comprising a pharmaceutically acceptable carrier and an active agent complexed with glycyrrhizin, wherein the active agent contains at least one nitrogen-containing moiety, and wherein the composition is substantially free of uncomplexed active agent.
2. The composition according to claim 1 , wherein the glycyrrhizin is selected from the group consisting of glycyrrhizin acid and its biologically acceptable salts.
3. The composition according to claim 2 , wherein the glycyrrhizinic acid is an 18-alpha glycyrrhizinic acid or 18-beta-glycyrrhizinic acid.
4. The composition according to claim 2 , wherein the glycyrrhizinic acid is ionically complexed with the active agent.
5. The composition according to claim 2 , wherein the active agent is famotidine.
6. The composition according to claim 2 , wherein the mole ratio of glycyrrbizinic acid to active agent is 1:1 to 1:3.
7. The composition according to claim 1 , wherein the mole ratio of glycyrrhizin to active agent is 1:1 to 1:3.
8. The composition according to claim 1 , wherein the nitrogen containing moiety is one or more of an acyclic or heterocycic amine, amide, imine, imide and nitrile.
9. The composition according to claim 1 , wherein the active agent comprises abortifacients, ACE inhibitors, adrenocorticotropic hormones, α-adrenergic agonists, α-adrenergnic blockers, α-glucosidase inhibitors, anabotic steroids, narcotic analgesics, non-narcotic analgesics, anorexics, anthelmintics, antiallergics, antialopecials, antianiebics, antianginals, antiarrhytbmics, antiartbritics, antiasthmatics, antibiotics, anticholinergics, anticonvulsants, antidepressants, antidiabetics, antidiarrheals, antidotes, antidyskinetics, antiemetics, antiestrogens, antifungals, antiglaucoma agents, antigout agents, antihistaminics, antihypertensives, nonsteroidal antiinflamatories, antimalarials, antimigraines, antineoplastics, antiparkinsonians, antipheochromocytoma agents, antipneumocystis agents, antiprostatic hyperplasia agents, antiprotozoals, antipruritics, antipsoriatics, antipsychotics, antipyretics, antirickettsials, antispasmodics, antithrombocythemics, antithrombotics, antitussives, antiulceratives, antivirals, anxiolytics, aromatase inhibitors, benzodiazepine antagonists, β-adrenergic antagonists,β-adrenergic blockers, bradycardic agents, bronchodilators, calcium channel blockers, carbonic anhydrase inhibitors, cardiotonics, choleretics, cholinergics, cholinesterase inhibitors, cholinesterase reactivators, CNS stimulants, cytoprotectants, decongestants, diuretics, dopamine receptor agonists, dopamine receptor antagonists, ectorarasiticides, emetics, expectorants, fibrinogen receptor antagonists, gastric secretion inhibitors, gastroprokinetics, hemostatics, histamine H 2 receptor antagonists, immunomodulators, immunosuppressants, keratolytics, MAO inhibitors, mucolytics, muscle relaxants, mydriatics, narcotic antagonists, nootropics, oxytocics, potassium channel activators, respiratory stimulants, sedatives, hypnotics, serenics, serotonin receptor agonists, serotonin receptor antagonists, serotonin uptake inhibitors, thrombolytics, tocolytics, vasodilators, and vasoprotectants.
10. A pharmaceutical dosage form comprising the composition of claim 1 .
11. The dosage form of claim 10 , wherein the dosage form is selected from the group consisting of a reconstituted powder, a soluble, and edible film sachet, a liquidfor oral or parenteral administration, an effervescent tablet, a chewable tablet, a mucosal surface-coating hydrocolloid film, a fast dissolving intraoral wafer, a troche, a lozenge, a nasal spray, a powder for inhalation, a mucoadhesive device for buccal, rectal or vaginal administration, a controlled release tablet and a capsule containing enteric microcapsules.
12. The dosage form of claim 10 , wherein the dosage form further comprises at least one reagent selected from the group consisting of a water soluble polymer, a water insoluble polymer, an emulsifier, a plasticizer, a taste modifier, a coloring agent, a preservative, a permeation enhancer, a stabilizer, an inert filler, a binder, a thickening agent, a buffering agent, a lipid vehicle, a metabolism inhibitor and a glidant.