Schizophrenia related gene
View Patent ↗The invention relates to polynucleotides of the PAPAP gene, polypeptides encoded by the PAPAP gene, and antibodies directed specifically against such polypeptides. The invention also concerns methods for the treatment or diagnosis of schizophrenia, bipolar disorder or related CNS disorder. The invention also concerns the interaction of PAPAP with schizophrenia candidate gene g34872.
1. An isolated polynucleotide selected from the group consisting of:
a) a polynucleotide encoding a polypeptide comprising an amino acid sequence selected from the group consisting of:
i) the amino acid sequence of SEQ ID NO:2; and
ii) an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:2 and binds to the polypeptide g34782 or binds to a calcium/calmodulin-dependent kinase II (CaM-KII);
b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1, SEQ ID NO:3, or the complement thereof; and
c) a polynucleotide that: (i) encodes a polypeptide binds to the polypeptide g34782 or binds to a calcium/calmodulin-dependent kinase II (CaM-KII); and (ii) has at least 95% identity to the nucleotide sequence of SEQ ID NO: 1 or 3.
2. The polynucleotide of claim 1 , further comprising a label.
3. The polynucleotide of claim 1 , wherein said polynucleotide is bound to a solid support.
4. The polynucleotide according to claim 1 , wherein said polynucleotide has at least 95% nucleotide identity with the polynucleotide of SEQ ID NO:1 and said polynucleotide encodes a polypeptide that binds to the polypeptide g34782 or to CaM-KII.
5. The polynucleotide according to claim 1 , wherein said polynucleotide has at least 95% nucleotide identity with the nucleotide sequence of SEQ ID NO:3 and said polynucleotide encodes a polypeptide that binds to the polypeptide g34782 or CaM-KII.
6. The polynucleotide according to claim 1 , wherein said polynucleotide encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2.
7. The polynucleotide according to claim 1 , wherein said polynucleotide encodes a polypeptide comprising an amino acid sequence which is at least 95% identical to the amino acid sequence of SEQ ID NO: 2 and binds to the polypeptide g34782 or binds to a calcium/calmodulin-dependent kinase II (CaM-KII).
8. The polynucleotide according to claim 1 , wherein said polynucleotide comprises the nucleotide sequence of SEQ ID NO:1 or the complement thereof.
9. The polynucleotide according to claim 1 , wherein said polynucleotide comprises the nucleotide sequence of SEQ ID NO:3 or the complement thereof.
10. A recombinant vector comprising the polynucleotide of claim 1 .
11. An isolated host cell comprising the recombinant vector of claim 10 .
12. A method for producing a polypeptide, said method comprising:
a) providing a host cell comprising the recombinant vector of claim 10 ; and
b) culturing said host cell under conditions conducive to the expression of said polypeptide.
13. The method of claim 12 , further comprising recovering the polypeptide produced by said host cell.