Method for treating neurogenic inflammation pain with botulinum toxin and substance P components
View Patent ↗The present invention relates to methods for treating neurogenic inflammation pain. The methods include administering an effective amount of a composition which includes a botulinum toxin component and a substance P component to a patient, thereby treating the neurogenic inflammation pain.
1. A method for treating neurogenic inflammation pain, the method comprises injecting a therapeutically effective amount of about 0.01 units to about 1,000 units of an agent to a patient, the agent comprising the light chain of a botulinum toxin covalently coupled to the H N portion of the heavy chain of the botulinum toxin, and a substance P component covalently coupled to the botulinum toxin H N portion, the substance P component being effective in binding to a substance P receptor, thereby treating the neurogenic inflammation pain for at least about two months.
2. The method of claim 1 wherein the botulinum toxin light chain is the light chain of a botulinum toxin selected from the group consisting of botulinum toxin serotype A, serotype B, serotype C, serotype D, serotype E, serotype F and serotype G.
3. The method of claim 1 wherein the botulinum toxin H N portion is the H N portion of a botulinum toxin selected from the group consisting of botulinum toxin serotype A, serotype B, serotype C, serotype D, serotype E, serotype F and serotype G.
4. The method of claim 2 wherein the light chain is a light chain of a botulinum toxin serotype A.
5. The method of claim 3 wherein the H N portion is an H N portion of a botulinum toxin serotype A.
6. The method of claim 1 wherein the substance P component is substance P.
7. The method of claim 1 wherein the pain is arthritis pain.
8. The method of claim 1 wherein the agent is injected subcutaneously.
9. The method of claim 1 wherein the agent is injected intramuscularly.
10. The method of claim 1 wherein the agent is injected in an amount from about 10 −2 U/kg to about 100 U/kg.
11. The method of claim 1 wherein the agent is injected in an amount from about 10 −1 U/kg to about 10 U/kg.
12. The method of claim 1 wherein the agent is injected in an amount from about 1 unit to about 20 units.
13. The method of claim 1 wherein the agent is injected in an amount from about 1 unit to about 10 units.
14. The method of claim 1 wherein the agent is injected in an amount from about 0.1 U/kg to about 30 U/kg.