IP Library Granted Patent US 6,906,044
Granted Patent B2
US 6,906,044 · App. 10/082,743 · Granted Jun 14, 2005

Regeneration of articular cartilage damaged by grade I and II osteoarthritis by means of the intraarticular application of a mixture of sodium hyaluronate and chondroitin sulfate in a gel vehicle

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Quick Facts
Patent No.
US 6,906,044
App. No.
10/082,743
Granted
Jun 14, 2005
Kind
B2
Abstract

Methods of treating osteochondral lesions by the intraarticular application of a mixture of sodium hyaluronate and chondroitin sulfate are disclosed.

Claims (5)

1. A therapeutic method for the treatment of a mammalian joint with articular cartilage exhibiting degeneration caused by osteoarthritis, comprising (i) the intraarticular implantation of a pharmaceutically effective amount of a viscoelastic composition comprising an aqueous vehicle with 40 mg of chondroitin sulfate and 30 mg of sodium hyaluronate per cubic centimeter of said vehicle.

2. The therapeutic method according to claim 1 , wherein the mammalian joint is a human joint, the intraarticular implantation is effected with a hypodermic needle, and the articular cartilage is selected from the group consisting of the following joints: i) knees, shoulders and sacroiliac; ii) coxofemoral, ankles and elbows; and iii) interphalangeal and wrists.

3. The therapeutic method according to claim 1 , in which the pharmaceutically effective amount comprises 1.5 cubic centimeters of the composition according to claim 1 for a joint selected from the group consisting of: knee, shoulder and sacroiliac.

4. The therapeutic method according to claim 1 , in which the pharmaceutically effective amount comprises 0.75 cubic centimeters of the composition according to claim 1 for a joint selected from the group consisting of: coxofemoral, ankle and elbow.

5. The therapeutic method according to claim 1 , in which the Pharmaceutically effective amount comprises 0.5 cubic centimeters of the compound according to claim 1 for a joint selected from the group consisting of interphalangeal and wrist.

Assignments (3)
CONFIRMATORY DEED OF ASSIGNMENT EFFECTIVE APRIL 8, 2019 Recorded Dec 10, 2019
From: NOVARTIS AG
To: ALCON INC.
Reel/Frame 051454/0788 →
MERGER Recorded May 31, 2011
From: ALCON, INC.
To: NOVARTIS AG
Reel/Frame 026376/0076 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 15, 2002
From: OCHOA, ELIAS HERMIDA
To: ALCON, INC.
Reel/Frame 013395/0338 →