Regeneration of articular cartilage damaged by grade I and II osteoarthritis by means of the intraarticular application of a mixture of sodium hyaluronate and chondroitin sulfate in a gel vehicle
View Patent ↗Methods of treating osteochondral lesions by the intraarticular application of a mixture of sodium hyaluronate and chondroitin sulfate are disclosed.
1. A therapeutic method for the treatment of a mammalian joint with articular cartilage exhibiting degeneration caused by osteoarthritis, comprising (i) the intraarticular implantation of a pharmaceutically effective amount of a viscoelastic composition comprising an aqueous vehicle with 40 mg of chondroitin sulfate and 30 mg of sodium hyaluronate per cubic centimeter of said vehicle.
2. The therapeutic method according to claim 1 , wherein the mammalian joint is a human joint, the intraarticular implantation is effected with a hypodermic needle, and the articular cartilage is selected from the group consisting of the following joints: i) knees, shoulders and sacroiliac; ii) coxofemoral, ankles and elbows; and iii) interphalangeal and wrists.
3. The therapeutic method according to claim 1 , in which the pharmaceutically effective amount comprises 1.5 cubic centimeters of the composition according to claim 1 for a joint selected from the group consisting of: knee, shoulder and sacroiliac.
4. The therapeutic method according to claim 1 , in which the pharmaceutically effective amount comprises 0.75 cubic centimeters of the composition according to claim 1 for a joint selected from the group consisting of: coxofemoral, ankle and elbow.
5. The therapeutic method according to claim 1 , in which the Pharmaceutically effective amount comprises 0.5 cubic centimeters of the compound according to claim 1 for a joint selected from the group consisting of interphalangeal and wrist.