IP Library › Granted Patent US 6,933,352
Granted Patent B2
US 6,933,352 · App. 10/083,555 · Granted Aug 23, 2005

Amphiphilic compounds having a dendritic branch structure

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Quick Facts
Patent No.
US 6,933,352
App. No.
10/083,555
Granted
Aug 23, 2005
Kind
B2
Abstract

An amphiphilic compound having a dendritic branch structure represented by general formula (I): In the formula (I), R 0 is a hydrophilic group; R 1 and R 2 are independently a hydrophobic group; and n is an integer of 1 to 4. This amphiphilic compound is capable of stably fixing a water-soluble polymer onto a surface structure by taking advantage of intermolecular interaction, thereby enabling the water-soluble polymer to be carried thereon without giving any damage to the function thereof.

Claims (26)

1. An amphiphilic compound having a dendritic branch structure having general formula (I):

which is selected from the group consisting of an amphiphilic compound having a dendritic branch structure represented by the following formula (G), an amphiphilic compound having a dendritic branch structure represented by the following formula (H), and an amphiphilic compound having a dendritic branch structure represented by the following formula (J):

where Fn x , Fn 1 , Fn 2 , Fn 3 , Fn 4 and Fn 5 respectively represents a functional reactive group, each of which is bonded to a neighboring functional reactive group; R 0 is a poly- or oligo-oxyethylene derivative, or a poly- or oligo-saccharide derivative; R 1 and R 2 are independently a hydrophobic group; and n is an integer of 2 to 4.

2. The amphiphilic compound according to claim 1 , wherein said functional reactive group is bonded through amide bond or ester bond.

3. An amphiphilic compound having a dendritic branch structure having general formula (II):

which is selected from the group consisting of an amphiphilic compound having a dendritic branch structure represented by the following formula (II-1), an amphiphilic compound having a dendritic branch structure represented by the following formula (II-2), an amphiphilic compound having a dendritic branch structure represented by the following formula (II-3), and an amphiphilic compound having a dendritic branch structure represented by the following formula (II-4):

where R 0 is a hydrophilic group; X is —(CH 2 ) 4 — or —(CH 2 ) p —CO— (wherein p is 1 or 2); each of R 1 and R 2 is independently an alkyl group; and n is an integer of 1 to 4.

4. The amphiphilic compound according to claim 3 , wherein said compound is represented by said formula (II-2), said formula (II-3) or said formula (II-4).

5. The amphiphilic compound according to claim 3 , wherein said alkyl group contains 1 to 30 carbon atoms.

6. The amphiphilic compound according to claim 3 , wherein said R 0 is poly- or oligo-oxyethylene derivative, poly- or oligo-saccharide derivative, or poly- or oligo-peptide.

7. The amphiphilic compound according to claim 4 , wherein said R 0 is poly- or oligo-oxyethylene derivative, poly- or oligo-saccharide derivative, or poly- or oligo-peptide.

8. The amphiphilic compound according to claim 3 , wherein said R 0 is represented by a formula:

R—(OCH 2 CH 2 ) m CH 2 NH— or R—(OCH 2 CH 2 ) m OCH 2 C(O)NHCH 2 CH 2 NH— where R is H—, CH 3 —, CH 3 C(O)—, HOOCCH 2 —, H 2 NCH 2 CH 2 NHC(O)CH 2 —, or poly- or oligo-peptides; and m is an integer of 1 to 3000.

9. The amphiphilic compound according to claim 4 , wherein said R 0 is represented by a formula:

R—(OCH 2 CH 2 ) m CH 2 NH— or R—(OCH 2 CH 2 ) m OCH 2 C(O)NHCH 2 CH 2 NH— where R is H—, CH 3 —, CH 3 C(O)—, HOOCCH 2 —, H 2 NCH 2 CH 2 NHC(O)CH 2 — or poly- or oligo-peptides; and m is an integer of 1 to 3000.

10. An amphiphilic compound having a dendritic branch structure having following general formula (III):

which is selected from the group consisting of an amphiphilic compound having a dendritic branch structure represented by the following formula (III-1), an amphiphilic compound having a dendritic branch structure represented by the following formula (III-2), an amphiphilic compound having a dendritic branch structure represented by the following formula (III-3), and an amphiphilic compound having a dendritic branch structure represented by the following formula (III-4):

where R 0 is a hydrophilic group; each of R 1 and R 2 is independently an alkyl group; n is an integer of 1 to 4 and q is 1 or 2.

11. The amphiphilic compound according to claim 10 , wherein said compound is represented by said formula (III-2), said formula (III-3) or said formula (III-4).

12. The amphiphilic compound according to claim 10 , wherein said alkyl group contains 1 to 30 carbon atoms.

13. The amphiphilic compound according to claim 10 , wherein said R 0 is poly- or oligo-oxyethylene derivative, poly- or oligo-saccharide derivative, or poly- or oligo-peptide.

14. The amphiphilic compound according to claim 11 , wherein said R 0 is poly- or oligo-oxyethylene derivative, poly- or oligo-saccharide derivative, or poly- or oligo-peptide.

15. The amphiphilic compound according to claim 10 , wherein said R 0 is represented by a formula:

R—(OCH 2 CH 2 ) m CH 2 NH— or R—(OCH 2 CH 2 ) m OCH 2 C(O)NHCH 2 CH 2 NH— (wherein R is H—, CH 3 —, CH 3 C(O)—, HOOCCH 2 —, H 2 NCH 2 CH 2 NHC(O)CH 2 — or poly- or oligo-peptides; and m is an integer of 1 to 3000.

16. The amphiphilic compound according to claim 11 , wherein said R 0 is represented by a formula:

R—(OCH 2 CH 2 ) m CH 2 NH— or R—(OCH 2 CH 2 ) m OCH 2 C(O)NHCH 2 CH 2 NH— wherein R is H—, CH 3 —, CH 3 C(O)—, HOOCCH 2 —, H 2 NCH 2 CH 2 NHC(O)CH 2 — or poly- or oligo-peptides; and m is an integer of 1 to 3000.