IP Library Granted Patent US 7,103,450
Granted Patent B2
US 7,103,450 · App. 10/084,089 · Granted Sep 5, 2006

Automated liquid manufacturing system

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Quick Facts
Patent No.
US 7,103,450
App. No.
10/084,089
Granted
Sep 5, 2006
Kind
B2
Abstract

A method for continuously preparing a medium formulation mixes a diluent with a plurality of chemically incompatible concentrate solutions in such a manner that none of the ingredients of the concentrate solutions chemically react in an adverse manner. The method utilizes a static mixing chamber to add the concentrate solutions to the diluent stream sufficiently in advance of one another so that adverse chemical reactions do not occur. The method also adjusts a pH level of the diluent prior to adding any of the concentrate solutions to the diluent.

Claims (36)

1. A computer program product for use with a computer system, said computer program product comprising:

a computer usable medium having computer readable program code means embodied in said medium for causing the computer system to control the continuous preparation of medium from concentrated solutions, said computer readable program code means comprising:

computer readable program code means for enabling the computer system to control a flow of a diluent into a static mixing chamber, wherein said static mixing chamber provides a turbulent diluent stream in accordance with said flow;

computer readable program code means for enabling the computer system to control a flow of a plurality of chemically incompatible concentrate solutions into said static mixing chamber, wherein said plurality of concentrate solutions admix with said turbulent diluent stream in such a manner that none of the ingredients of the concentrate solutions adversely chemically react with each other to thereby form a diluted mixture of said concentrate solutions; and

computer readable program code means for enabling the computer system to monitor a pH level of said diluted mixture using at least one pH sensor located downstream of said static mixing chamber.

2. The computer program product of claim 1 , further comprising:

computer readable program code means for enabling the computer system to monitor a flow of said diluted mixture out of said static mixing chamber, as measured by a flow sensor.

3. The computer program product of claim 2 , further comprising:

computer readable program code means for enabling the computer system to adjust the flow of said diluent and the flow of said plurality of concentrate solutions based on the flow of said diluted mixture.

4. The computer program product of claim 1 , further comprising:

computer readable program code means for enabling the computer system to monitor a level of said diluted mixture in a medium surge tank; and

computer readable program code means for enabling the computer system to adjust the flow of said diluted mixture into said medium surge tank.

5. The computer program product of claim 4 , wherein said computer readable program code means for enabling the computer system to adjust the flow of said diluted mixture into said medium surge tank comprises:

computer readable program code means for enabling the computer system to adjust the flow of said diluent into said static mixing chamber; and

computer readable program code means for enabling the computer system to adjust the flow of said plurality of concentrate solutions into said static mixing chamber.

6. The computer program product of claim 1 , further comprising:

computer readable program code means for enabling the computer system to monitor a parameter of said diluted mixture using a sensor located downstream from said static mixing chamber to determine whether said diluted mixture is acceptable.

7. The computer program product of claim 6 , further comprising:

computer readable program code means for enabling the computer system to control a diverter valve that directs said diluted mixture based on whether said diluted mixture is acceptable.

8. The computer program product of claim 1 , further comprising:

computer readable program code means for enabling the computer system to adjust a pH level of said diluted mixture.

9. The computer program product of claim 8 , wherein said computer readable program code means for enabling the computer system to adjust a pH level of said diluted mixture comprises:

computer readable program code means for enabling the computer system to adjust a flow of an acid solution into said static mixing chamber to thereby adjust the pH level of said diluted mixture.

10. The computer program product of claim 8 , wherein said computer readable program code means for enabling the computer system to adjust a pH level of said diluted mixture comprises:

computer readable program code means for enabling the computer system to adjust a flow of a caustic solution into said static mixing chamber to thereby adjust the pH level of said diluent stream.

11. The computer program product of claim 8 , wherein said computer readable program code means for enabling the computer system to adjust a pH level of said diluted mixture comprises:

computer readable program code means for enabling the computer system to adjust a flow of an acid solution into said static mixing chamber; and

computer readable program code means for enabling the computer system to adjust a flow of a caustic solution into said static mixing chamber.

12. The computer program product of claim 5 , wherein said computer readable program code means for enabling the computer system to adjust the flow of said plurality of concentrate solutions into said static mixing chamber comprises:

computer readable program code means for enabling the computer system to adjust a flow rate of an acid soluble concentrate solution into said static mixing chamber.

13. The computer program product of claim 5 , wherein said computer readable program code means for enabling the computer system to adjust the flow of said plurality of concentrate solutions into said static mixing chamber comprises:

computer readable program code means for enabling the computer system to adjust a flow of a group I salt concentrate solution into said static mixing chamber.

14. The computer program product of claim 5 , wherein said computer readable program code means for enabling the computer system to adjust the flow of said plurality of concentrate solutions into said static mixing chamber comprises:

computer readable program code means for enabling the computer system to adjust a flow of a group II salt concentrate solution into said static mixing chamber.

15. The computer program product of claim 5 , wherein said computer readable program code means for enabling the computer system to adjust the flow of said plurality of concentrate solutions into said static mixing chamber comprises:

computer readable program code means for enabling the computer system to adjust a flow of a base soluble concentrate solution into said static mixing chamber.

Assignments (4)
CORRECTIVE ASSIGNMENT TO CORRECT THE APPLICATION NO 09452626 PREVIOUSLY RECORDED ON REEL 023882 FRAME 0551. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER SHOULD NOT HAVE BEEN RECORDED AGAINST THIS PATENT APPLICATION NUMBER. Recorded Nov 14, 2014
From: INVITROGEN CORPORATION
To: LIFE TECHNOLOGIES CORPORATION
Reel/Frame 034217/0490 →
LIEN RELEASE Recorded Apr 9, 2013
From: BANK OF AMERICA, N.A.
To: LIFE TECHNOLOGIES CORPORATION
Reel/Frame 030182/0461 →
MERGER Recorded Feb 3, 2010
From: INVITROGEN CORPORATION
To: LIFE TECHNOLOGIES CORPORATION
Reel/Frame 023882/0551 →
SECURITY AGREEMENT Recorded Dec 5, 2008
From: LIFE TECHNOLOGIES CORPORATION
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 021975/0467 →