Intraluminal device, coating for such device, and method for preparing said device
Disclosed is an intraluminal device, suitable for implantation in a body. The intraluminal device is provided with a coating which comprises: 50-97% heparan sulfate; 1-20% laminin; 0.2-15% type IV collagen. Furthermore a coating is disclosed, which coating is suitable for the above mentioned device, as well as a method for preparing such device, comprising the steps of: providing a intraluminal device for implantation in a body; preparing a composition, comprising, in about 50 mg/ml solvent: 50-97% heparan sulfate; 1-20% laminin; 0.2-15% type IV collagen; the solvent being a suitable buffer or water; dipping the intraluminal device in the composition; and drying the dipped intraluminal device.
1. An intraluminal device, suitable for implantation in a body, which device is provided with a coating, wherein the coating comprises:
50-97% heparan sulfate;
1-20% laminin; and
0.2-15% type IV collagen.
2. The intraluminal device according to claim 1 , wherein the coating comprises:
75-95% heparan sulfate;
3-10% laminin; and
0.5-10% type IV collagen.
3. The intraluminal device according to claim 1 , wherein the coating further comprises a growth factor.
4. The intraluminal device according to claim 3 , wherein the growth factor is selected from the group consisting of bFGF, IGF, TGF-β and VEGF.
5. An intraluminal device, suitable for implantation in a body, the device being provided with a coating that comprises:
50-97% heparan sulfate;
1-20% laminin;
0.2-15% type IV collagen; and
an antibiotic.
6. An intraluminal device, suitable for implantation in a body, the device being provided with a coating that comprises:
50-97% heparan sulfate;
1-20% laminin;
0.2-15% type IV collagen; and
an antibiotic comprising gentamycine.
7. The intraluminal device according to claim 1 , wherein the coating further comprises vitronectine.
8. The intraluminal device according to claim 1 , wherein the coating comprises:
85-95% heparan sulfate;
5-6% laminin;
3-4% type IV collagen;
0.5-1.5% entactin and nidogen;
0.001-1% growth factors; and
0.001-1% antibiotic.
9. The intraluminal device according to claim 1 , wherein the intraluminal device is a prosthesis that comprises a stent or a graft.
10. A coating suitable for the intraluminal device according to claim 1 .
11. A method for preparing an intraluminal device, comprising the steps of:
providing an intraluminal device for implantation in a body;
preparing a composition, comprising, in about 50 mg/ml solvent:
50-97% heparan sulfate;
1-20% laminin;
0.2-15% type IV collagen; and
the solvent being a suitable buffer or water;
dipping the intraluminal device in the composition; and
drying the dipped intraluminal device.
12. The method according to claim 11 , wherein the composition further comprises entactin and nidogen.
13. The method according to claim 11 , wherein the composition further comprises a growth factor, selected from the group consisting of bFGF, IGF, TGF-β and VEGF.
14. The method according to claim 11 , wherein the composition further comprises an antibiotic.
15. The method according to claim 11 , wherein the composition further comprises vitronectin.
16. The method according to claim 11 , wherein the composition comprises:
85-95% heparan sulfate;
5-6% laminin;
3-4% type IV collagen;
0.5-1.5% entactin and nidogen;
0.001-1% growth factors; and
0.001-1% antibiotic.
17. The intraluminal device according to claim 1 , wherein the coating further comprises entactin and nidogen.