Glycopeptide derivatives and pharmaceutical compositions containing the same
View Patent ↗Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —R a —Y—R b —(Z) x where R a , R b , Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
1. A compound of formula II:
wherein
R 16 is hydrogen or methyl;
R 26 is hydrogen or methyl;
R 27 is hydrogen or —CH 2 COOH;
R a is —CH 2 CH 2 —, —CH 2 CH 2 CH 2 — or —CH 2 CH 2 CH 2 CH 2 —;
R b is alkylene having from 8 to 12 carbon atoms;
and pharmaceutically acceptable salts, stereoisomers and prodrugs thereof.
2. The compound of claim 1 , wherein R 16 is methyl.
3. The compound of claim 1 , wherein R 26 is methyl.
4. The compound of claim 1 , wherein R 27 is hydrogen.
5. The compound of claim 1 , wherein R a is —CH 2 CH 2 —.
6. The compound of claim 1 , wherein —R b —H is an n-octyl, n-nonyl, n-decyl, n-undecyl or n-dodecyl group.
7. The compound of claim 1 , wherein —R b —H is an n-decyl group.
8. The compound of claim 1 , wherein R 15 is —CH 2 CH 2 —NH—(CH 2 ) 10 —H.
9. A pharmaceutical composition comprising a compound of any of claims 1 - 8 and a pharmaceutically acceptable carrier.
10. A method of inhibiting the growth of bacteria in a mammal infected with or exposed to bacteria, the method comprising administering to the mammal a composition according to claim 9 for a time and under conditions effective to inhibit growth of bacteria.