Human secreted proteins
View Patent ↗The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding the polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to the human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing the polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
1. An isolated polypeptide comprising amino acid residues 20 to 283 of SEQ ID NO:5761.
2. The isolated polypeptide of claim 1 which comprises amino acid residues 2 to 283 of SEQ ID NO:5761.
3. The isolated polypeptide of claim 1 which comprises amino acid residues 1 to 283 of SEQ ID NO:5761.
4. The polypeptide of claim 1 which further comprises a polypeptide sequence heterologous to SEQ ID NO:5761.
5. A composition comprising the polypeptide of claim 1 and a carrier.
6. An isolated protein produced by the method comprising:
(a) expressing the polypeptide of claim 1 by a cell; and
(b) recovering said protein.
7. An isolated polypeptide comprising the amino acid sequence of the secreted portion of the polypeptide encoded by the HDPPA04 cDNA contained in American Type Culture Collection (ATCC) Deposit No. PTA-867.
8. The isolated polypeptide of claim 7 which comprises the amino acid sequence of the complete polypeptide encoded by the HDPPA04 cDNA contained in ATCC Deposit No. PTA867, excepting the N-terminal methionine.
9. The isolated polypeptide of claim 7 which comprises the amino acid sequence of the complete polypeptide encoded by the HDPPA04 cDNA contained in ATCC Deposit No. PTA-867.
10. The polypeptide of claim 7 which further comprises a polypeptide sequence heterologous to the HDPPA04 cDNA contained in ATCC Deposit No. PTA-867.
11. A composition comprising the polypeptide of claim 7 and a carrier.
12. An isolated protein produced by the method comprising:
(a) expressing the polypeptide of claim 7 by a cell; and
(b) recovering said protein.
13. An isolated first polypeptide at least 90% identical to a second polypeptide comprising amino acid residues 20 to 283 of SEQ ID NO:5761, wherein said first polypeptide generates an antibody the specifically binds the polypeptide of SEQ ID NO:5761.
14. The isolated polypeptide of claim 13 , wherein said first polypeptide is at least 95% identical to said second polypeptide.
15. The isolated polypeptide of claim 13 which further comprises a polypeptide sequence heterologous to SEQ ID NO:5761.
16. A composition comprising the isolated polypeptide of claim 13 and a carrier.
17. An isolated protein produced by the method comprising:
(a) expressing the isolated polypeptide of claim 13 by a cell; and
(b) recovering said isolated protein.
18. An isolated first polypeptide at least 90% identical to a second polypeptide comprising amino acid residues 10 to 283 of SEQ ID NO:5761, wherein said first polypeptide generates an antibody the specifically binds the polypeptide of SEQ ID NO:5761.
19. The isolated polypeptide of claim 18 wherein said first polypeptide is at least 95% identical to said second polypeptide.
20. The isolated polypeptide of claim 18 which further comprises a polypeptide sequence heterologous to SEQ ID NO:5761.
21. A composition comprising the isolated polypeptide of claim 18 and a carrier.
22. An isolated protein produced by the method comprising:
(a) expressing the isolated polypeptide of claim 18 by a cell; and
(b) recovering said isolated protein.
23. An isolated first polypeptide at least 90% identical to a second polypeptide comprising the secreted portion of the polypeptide encoded by the HDPPA04 cDNA contained in ATCC Deposit No. PTA-867 wherein said first polypeptide generates an antibody that specifically binds the polypeptide of SEQ ID NO:5761.
24. The isolated polypeptide of claim 23 , wherein said first polypeptide sequence is at least 95% identical to said second polypeptide.
25. The isolated polypeptide of claim 23 which further comprises a polypeptide sequence heterologous to SEQ ID NO:5761.
26. A composition comprising the isolated polypeptide of claim 23 and a carrier.
27. An isolated protein produced by the method comprising:
(a) expressing the isolated polypeptide of claim 23 by a cell; and
(b) recovering said isolated protein.
28. An isolated first polypeptide at least 90% identical to a second polypeptide comprising the complete polypeptide encoded by the HDPPA04 cDNA contained in ATCC Deposit No. PTA-867, wherein said first polypeptide generates an antibody that specifically binds the polypeptide of SEQ ID NO:5761.
29. The isolated polypeptide of claim 28 , wherein said first polypeptide sequence is at least 95% identical to said second polypeptide.
30. The isolated polypeptide of claim 28 which further comprises a polypeptide sequence heterologous to SEQ ID NO:5761.
31. A composition comprising the isolated polypeptide of claim 28 and a carrier.
32. An isolated protein produced by the method comprising:
(a) expressing the isolated polypeptide of claim 28 by a cell; and
(b) recovering said isolated protein.
33. An isolated first polypeptide at least 50 contiguous amino acid residues of amino acid residues 1 to 283 of SEQ ID NO:5761, wherein said first polypeptide generates an antibody that specifically binds the polypeptide of SEQ ID NO:5761.
34. The polypeptide of claim 33 which further comprises a polypeptide sequence heterologous to SEQ ID NO:5761.
35. A composition comprising the polypeptide of claim 33 and a carrier.
36. An isolated protein produced by the method comprising:
(a) expressing the polypeptide of claim 33 by a cell; and
(b) recovering said protein.
37. An isolated first polypeptide at least 50 contiguous amino acid residues of the complete polypeptide comprising the complete polypeptide encoded by the HDPPA04 cDNA contained in ATCC Deposit No. PTA-867, wherein said first polypeptide generates an antibody that specifically binds the polypeptide of SEQ ID NO:5761.
38. The polypeptide of claim 37 which further comprises a polypeptide sequence heterologous to the HDPPA04 cDNA contained in ATCC Deposit No. PTA-867.
39. A composition comprising the polypeptide of claim 37 and a carrier.
40. An isolated protein produced by the method comprising:
(a) expressing the polypeptide of claim 37 by a cell, and recovering said protein.