High efficacy antibacterial compositions having enhanced esthetic and skin care properties
View Patent ↗Antibacterial compositions having high antibacterial effectiveness and excellent esthetic properties are disclosed. The compositions also impart skin conditioning properties and improved feel to cleansed skin. The antibacterial compositions contain a phenolic antibacterial agent, a surfactant, esthetic enhancers, skin care ingredients, and water, wherein a percent saturation of the antibacterial agent in the aqueous phase of the composition is at least 25%.
1. An antibacterial composition comprising:
(a) about 0.001% to about 10%, by weight, of a phenolic antimicrobial agent selected from the group consisting of triclosan, p-chloro-m-xylenol, and mixtures thereof;
(b) about 0.1% to about 40%, by weight, of a surfactant selected from the group consisting of an anionic surfactant, a cationic surfactant, an ampholytic surfactant, and mixtures thereof;
(c) about 1% to about 40%, by weight, of a hydrotrope;
(d) about 1% to about 25%, by weight, of a water-soluble hydric solvent;
(e) about 0.1% to about 3%, by weight, of a skin-care agent selected from the group consisting of a polyvinylpyrrolidone polymer, a protein derivative, a glyceryl ester, an ethoxylated fatty ether, a cellulosic, a derivatized cellulosic, a polyethylene oxide, a cationic quaternary ammonium polymer, N-stearylmorpholine lactate, PPG-1 hydroxyethyl caprylamide, PPG-2 cocamide, a poly(sodium styrene sulfonate), and mixtures thereof;
(f) 0% to about 1.5%, by weight, of a foam stabilizer selected from the group consisting of a C 10 -C 22 fatty alcohol, a C 10 -C 22 fatty acid, and mixtures thereof;
(g) 0% to about 5%, by weight, of a humectant; and
(h) water,
wherein the composition contains at least one of (f) and (g),
and wherein the antimicrobial agent is present in an amount of at least 40% of saturation concentration, when measured at room temperature.
2. The composition of claim 1 containing each of (f), and (g).
3. The composition of claim 1 having a log reduction against Gram positive bacteria of at least 2 after 30 seconds of contact, as measured against S. aureus.
4. The composition of claim 1 having a log reduction against Gram negative bacteria of at least 2.5 after 30 seconds of contact, as measured against E. coli.
5. The composition of claim 1 having a log reduction against Gram positive bacteria of at least 2 after 30 seconds of contact, as measured against S. aureus , and a log reduction against Gram negative bacteria of at least 2.5 after 30 seconds of contact, as measured against E. coli.
6. The composition of claim 1 wherein the antibacterial agent is present in an amount of at least 50% of saturation concentration.
7. The composition of claim 1 wherein the antibacterial agent is present in an amount of at least 75% of saturation concentration.
8. The composition of claim 1 comprising about 0.05% to about 2% by weight, of the phenolic antibacterial agent.
9. The composition of claim 1 wherein the surfactant is present in an amount of about 0.5% to about 15%, by weight of the composition.
10. The composition of claim 1 wherein the surfactant comprises an anionic surfactant.
11. The composition of claim 1 wherein the surfactant comprises an ampholytic surfactant.
12. The composition of claim 1 wherein the surfactant is selected from the group consisting of a C 8 -C 18 alkyl sulfate, an alkamidopropyl betaine, an alkylglucoside, a C 8 -C 18 alkamine oxide, and mixtures thereof.
13. The composition of claim 1 wherein the surfactant comprises lauryl sulfate, octyl sulfate, 2-ethylhexyl sulfate, cocamidopropyl betaine, cocoglucoside, lauramine oxide, and mixtures thereof.
14. The composition of claim 1 having a pH of about 5 to about 8.
15. The composition of claim 1 wherein the hydrotrope is present in an amount of about 5% to about 20% by weight.
16. The composition of claim 1 wherein the hydrotrope is selected from the group consisting of sodium cumene sulfonate, ammonium cumene sulfonate, ammonium xylene sulfonate, potassium toluene sulfonate, sodium toluene sulfonate, sodium xylene sulfonate, toluene sulfonic acid, xylene sulfonic acid, sodium polynaphthalene sulfonate, sodium polystyrene sulfonate, sodium methyl naphthalene sulfonate, disodium succinate, and mixtures thereof.
17. The composition of claim 1 wherein the hydric solvent is present in an amount of about 5% to about 15% by weight.
18. The composition of claim 1 wherein the hydric solvent comprises an alcohol, a diol, and mixtures thereof.
19. The composition of claim 18 wherein the hydric solvent comprises methanol, ethanol, isopropyl alcohol, n-butanol, n-propyl alcohol, ethylene glycol, propylene glycol, diethylene glycol, dipropylene glycol, tripropylene glycol, hexylene glycol, butylene glycol, PEG-4, or mixtures thereof.
20. The composition of claim 1 wherein the skin care agent is selected from the group consisting of a derivatized guar gum, hydroxyethylcellulose, hydroxypropylmethylcellulose, a derivatized hydroxyethylcellulose, a polyethylene glycol, a methoxypolyethylene glycol, a hydrolyzed wheat protein, a polyoxyethylene stearyl ether, and an ethoxylated glyceryl C 8 -C 18 ester.
21. The composition of claim 1 wherein the foam stabilizer is selected from the group consisting of cetyl alcohol, cetearyl alcohol, stearic acid, and mixtures thereof.
22. The composition of claim 1 wherein the humectant is selected from the group consisting of glycerin, sodium pyrrolidone carboxylate, and mixtures thereof.