Methods and compositions for the treatment of cerebral palsy
View Patent ↗The invention provides for the use of a botulinum toxin to treat cerebral palsy in juvenile patients by transdermal administration of the botulinum toxin. The juvenile patients are preferably juveniles of up to 6 years in age.
1. A method for treating juvenile cerebral palsy, the method comprising the step of transdermal administration of a botulinum toxin type A to a juvenile cerebral palsy patient, thereby treating juvenile cerebral palsy.
2. The method of claim 1 wherein the botulinum toxin type A is transdermally administered into a spastic muscle of the patient.
3. The method of claim 1 wherein the botulinum toxin type A is transdermally administered into a calf muscle or hamstring of the patient.
4. The method of claim 1 , wherein the transdermal administration step is carried out by contacting a skin surface of the patient with a botulinum toxin depot which can release the botulinum toxin type A for absorption through the skin of the patient.
5. The method of claim 4 , wherein the botulinum toxin depot is an adhesive patch which comprises a polymeric carrier for the botulinum toxin type A.
6. A method of treating juvenile cerebral palsy, the method comprising the step of transdermal administration of a therapeutically effective amount of a botulinum toxin type A to a juvenile cerebral palsy patient by contacting a skin surface of the patient with a botulinum toxin type A depot comprising a polymeric carrier which carrier can release the botulinum toxin type A for absorption through the skin surface of the patient, thereby treating juvenile cerebral palsy.
7. The method of claim 6 , further comprising the step of pretreatment of the skin with a skin permeation enhancer prior to contacting the skin surface of the patient with the botulinum toxin type A depot.
8. The method of claim 7 , further comprising the step of iontophoresis of the skin after the pretreatment step to thereby further enhance transdermal delivery of the botulinum toxin.
9. A method of treating a juvenile cerebral palsy, the method comprising the steps of:
(a) pretreatment of a skin surface of a juvenile cerebral palsy patient with a skin permeation enhancer;
(b) transdermal administration of a therapeutically effective amount of a botulinum toxin type A to a juvenile cerebral palsy patient by contacting the skin surface of the patient with a botulinum toxin type A depot comprising a polymeric carrier which carrier can release the botulinum toxin type A for absorption through the skin surface of the patient, and;
(c) iontophoresis of the skin to further enhance transdermal delivery of the botulinum toxin, thereby treating juvenile cerebral palsy.