IP Library Granted Patent US 6,881,403
Granted Patent B2
US 6,881,403 · App. 10/105,076 · Granted Apr 19, 2005

Tampon for the treatment of Streptococcus Group B infections of the vagina

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Quick Facts
Patent No.
US 6,881,403
App. No.
10/105,076
Granted
Apr 19, 2005
Kind
B2
Abstract

A tampon for treatment of Streptococcus Group B infections of the vagina is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering the lytic enzyme.

Claims (14)

1. A tampon for treating a Group B Streptococcus infection of the vagina comprising:

(i) an effective amount of a lytic enzyme genetically coded for by a bacteriophage specific for said Group B Streptococcus , said lytic enzyme being specific for said Group B Streptococcus whereby said lytic enzyme has the ability to digest a cell wall of said Group B Streptococcus ; and

(ii) a tampon carrier for delivering said lytic enzyme to the vagina.

2. The tampon of claim 1 , further comprising a buffer that maintains a pH of the composition at a range between about 4.0 and 9.0.

3. The tampon of claim 2 , wherein the buffer maintains the pH of the composition at the range between 5.5. and 7.5.

4. The tampon of claim 2 , wherein said buffer comprises a reducing agent.

5. The tampon of claim 4 , wherein said reducing agent is dithiothreitol.

6. The tampon of claim 2 , wherein said buffer comprises a metal chelating reagent.

7. The tampon of claim 6 , wherein said metal chelating reagent is ethylenediaminetetracetic disodium salt.

8. The tampon of claim 2 , wherein said buffer is a citrate-phosphate buffer.

9. The tampon of claim 1 , further comprising a bactericidal or bacteriostatic agent as a preservative.

10. The tampon of claim 1 , wherein said lytic enzyme is lyophilized.

11. The tampon according to claim 1 , wherein said at least one lytic enzyme is present in a concentration of about 100 to about 100,000 active enzyme units per milliliter of fluid in the wet environment of the nasal or oral passages.

12. The tampon according to claim 11 , wherein said at least one lytic enzyme is present in a concentration of about 100 to about 10,000 active enzyme units per milliliter of fluid in the wet environment of the nasal or oral passages.

Assignments (1)
RELEASE OF PATENT SECURITY AGREEMENTS RECORDED ON JUNE 15, 2018, REEL/FRAME 046392/0343; JUNE 15, 2018, REEL/FRAME 046104/0316; AND SEPTEMBER 25, 2020, REEL/FRAME 053885/0975. Recorded Mar 4, 2021
From: BMO HARRIS BANK N.A., AS ADMINISTRATIVE AGENT
To: RIDDELL, INC.; RIDDELL SPORTS GROUP, INC.
Reel/Frame 056455/0421 →