IP Library › Granted Patent US 6,916,961
Granted Patent B2
US 6,916,961 · App. 10/108,945 · Granted Jul 12, 2005

β2-adrenergic receptor agonists

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Quick Facts
Patent No.
US 6,916,961
App. No.
10/108,945
Granted
Jul 12, 2005
Kind
B2
Abstract

Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.

Claims (12)

1. A compound of the formula:

wherein

(i) R x , R y , and R z are each hydrogen; or

(ii) R x is hydrogen or PG 1 , R y is hydrogen or PG 2 , and R z is PG 1 , wherein PG 1 and PG 2 are amino protecting groups;

or a salt thereof.

2. The compound of claim 1 wherein R x , R y , and R z are each hydrogen.

3. The compound of claim 1 , wherein PG 1 and PG 2 are each independently selected from the group consisting of tert-butoxycarbonyl, benzyl, benzyloxycarbonyl, fluorenylmethoxycarbonyl, and allyloxycarbonyl.

4. The compound of claim 3 , wherein R x is benzyl, R y is hydrogen, and R z is benzyl.

5. The compound of claim 3 , wherein R x is benzyl, R y is tert-butoxycarbonyl, and R z is benzyl.

6. The compound of claim 3 , wherein R x is hydrogen, R y is hydrogen, and R z is benzyl.

7. The compound of claim 1 , wherein the compound has the formula

8. The compound of claim 1 , wherein the compound has the formula

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 9, 2014
From: THERAVANCE, INC.
To: THERAVANCE BIOPHARMA R&D IP, LLC
Reel/Frame 033181/0693 →