Aryloxy propanolamines for improving livestock production
View Patent ↗Disclosed is a compound represented by structural formula (I): R1 is a substituted or unsubstituted aryl group. R2 and R3 are independently —H, a C1-C4 straight chained or branched alkyl group. R4 and R5 are independently —H, a C1-C4 straight chained or branched alkyl group or, taken together with the nitrogen atom to which each is bonded, a non-aromatic heterocyclic ring. Ring A and Ring B are independently further substituted with zero, one or two substituents. Physiologically acceptable salts of structural formula shown above are also included. Also disclosed is a method promoting growth, efficiency of feed utilization and/or production of lean body mass in a livestock animal. The method comprises administering to the animal an effective amount of one or more compounds represented by the structural formula as shown or a physiologically acceptable salt thereof.
1. A compound represented by the following structural formula:
or a physiologically acceptable salt thereof, wherein R1 is represented by a structural formula selected from the group consisting of:
2. A compound represented by the following structural formula:
or a physiologically acceptable salt thereof.
3. The ammonium chloride, ammonium oxalate, ammonium acetate or ammonium 4-hydroxybenzoate salt of the compound of claim 2 .
4. A method of promoting growth, efficiency of feed utilization and/or production of lean body mass in a livestock animal, comprising administering to the animal an effective amount of a compound represented by the following structural formula:
or a physiologically acceptable salt thereof, wherein R1 is represented by a structural formula selected from the group consisting of:
5. The method of claim 4 wherein the animal is a ruminant.
6. The method of claim 5 wherein the ruminant is a cow, bull, heifer or steer.
7. The method of claim 4 wherein the animal is an avian.
8. The method of claim 7 wherein the avian is a chicken, turkey or duck.
9. A method of promoting growth, efficiency of feed utilization and/or production of lean body mass in a livestock animal, comprising administering to the animal an effective amount of a compound represented by the following structural formula:
or a physiologically acceptable salt thereof.
10. The method of claim 9 wherein the animal is a ruminant.
11. The method of claim 10 wherein the ruminant is a cow, bull, heifer or steer.
12. The method of claim 11 comprising administering the ammonium chloride, ammonium oxalate, ammonium acetate or ammonium 4-hydroxybenzoate salt of the compound.
13. The method of claim 9 wherein the animal is an avian.
14. The method of claim 13 wherein the avian is a chicken, turkey or duck.
15. The method of claim 14 comprising administering the ammonium chloride, ammonium oxalate, ammonium acctate or ammonium 4-hydroxybenzoate salt of the compound.
16. A method of increasing the quantity of meat or improving the quality of meat obtained from a livestock animal, comprising administering to the animal an effective amount of one or more compounds represented by the following structural formula:
or a physiologically acceptable salt thereof, wherein R1 is represented by a structural formula selected from the group consisting of:
17. A method of increasing the quantity of meat or improving the quality of meat obtained from a livestock animal, comprising administering to the animal an effective amount of one or more compounds represented by the following structural formula:
or a physiologically acceptable salt thereof.
18. The method of claim 17 comprising administering the ammonium chloride, ammonium oxalate, ammonium acetate or ammonium 4-hydroxybenzoate salt of the compound.
19. An animal feed premix comprising a compound of Structural Formula I, as defined in claim 1 , or a physiologically acceptable salt or solvate thereof, in association with a suitable carrier therefor.
20. An animal feed premix as claimed in claim 19 , wherein the compound is
or a physiologically acceptable salt or solvate thereof.
21. An animal feed composition comprising a compound of Structural Formula I, as defined in claim 1 , or a physiologically acceptable salt or solvate thereof, in association with a suitable carrier therefor.
22. An animal feed composition as claimed in claim 21 , wherein the compound is
or a physiologically acceptable salt or solvate thereof.