IP Library › Granted Patent US 6,846,841
Granted Patent B2
US 6,846,841 · App. 10/112,921 · Granted Jan 25, 2005

Anti-angiogenic compositions and methods of use

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Quick Facts
Patent No.
US 6,846,841
App. No.
10/112,921
Granted
Jan 25, 2005
Kind
B2
Abstract

The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.

Claims (15)

1. A method for embolizing a blood vessel, comprising delivering into said vessel a therapeutically effective amount of a composition comprising a compound which disrupts microtubule function, wherein said compound is paclitaxel, or an analogue or derivative thereof, such that said blood vessel is effectively occluded.

2. The method according to claim 1 wherein said paclitaxel, or an analogue or derivative thereof is paclitaxel.

3. The method according to claim 1 or 2 wherein said composition further comprises a polymeric carrier.

4. The method according to claim 3 wherein said composition is formed into microspheres.

5. The method according to claim 3 wherein said polymeric carrier is poly(ethylene-vinyl acetate) crosslinked with 40% vinyl acetate.

6. The method according to claim 3 , wherein said polymeric carrier is poly(lactic-co-glycolic acid).

7. The method according to claim 3 wherein said polymeric carrier is poly(caprolactone).

8. The method according to claim 3 wherein said polymeric carrier is poly(lactic acid).

9. The method according to claim 3 wherein said polymeric carrier is a copolymer of poly(lactic acid) and poly(caprolactone).

10. The method according to claim 3 wherein said polymeric carrier is a copolymer of poly(ethylene-vinyl acetate) crosslinked with 40% vinyl acetate, and poly(lactic acid).

11. The method according to claim 1 or 2 wherein said blood vessel nourishes a tumor.

12. The method according to claim 1 or 2 wherein said blood vessel nourishes a non-tumorigenic, angiogenesis-dependent disease.

13. The method according to claim 3 wherein said blood vessel nourishes a tumor.

14. The method according to claim 3 wherein said blood vessel nourishes a non-tumorigenic, angiogenesis-dependent disease.

15. The method according to claim 3 wherein said polymeric carrier is biodegradable.

Assignments (10)
RELEASE OF SECURITY INTEREST : RECORDED AT REEL/FRAME - 049288/0184 Recorded Jan 29, 2021
From: CAPITAL ONE, NATIONAL ASSOCIATION
To: ANGIOTECH PHARMACEUTICALS, INC.
Reel/Frame 055171/0634 →
RELEASE OF SECURITY INTEREST : RECORDED AT REEL/FRAME - 049104/0392 Recorded Jan 29, 2021
From: CAPITAL ONE, NATIONAL ASSOCIATION
To: SURGICAL SPECIALTIES CORPORATION LIMITED
Reel/Frame 055171/0674 →
SECURITY INTEREST Recorded May 26, 2019
From: ANGIOTECH PHARMACEUTICALS, INC.
To: CAPITAL ONE, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 049288/0184 →
SECURITY INTEREST Recorded May 7, 2019
From: SURGICAL SPECIALTIES CORPORATION LIMITED
To: CAPITAL ONE, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 049104/0392 →
RELEASE OF SECURITY INTEREST Recorded May 7, 2019
From: VIRTUS GROUP, LP, AS ADMINISTRATIVE AGENT FOR THE LENDERS
To: SURGICAL SPECIALTIES CORPORATION LIMITED
Reel/Frame 049106/0173 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE ADDRESS PREVIOUSLY RECORDED ON REEL 042115 FRAME 0140. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Aug 8, 2017
From: ANGIOTECH PHARMACEUTICALS, INC.
To: SURGICAL SPECIALTIES CORPORATION LIMITED
Reel/Frame 043332/0360 →
SECURITY INTEREST Recorded Apr 5, 2017
From: SURGICAL SPECIALTIES CORPORATION LIMITED
To: VIRTUS GROUP, LP
Reel/Frame 041860/0980 →
PARTIAL RELEASE OF SECURITY INTEREST Recorded Apr 5, 2017
From: VIRTUS GROUP, LP
To: ANGIOTECH PHARMACEUTICALS, INC.
Reel/Frame 042166/0029 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 28, 2017
From: ANGIOTECH PHARMACEUTICALS, INC.
To: SURGICAL SPECIALTIES CORPORATION LIMITED
Reel/Frame 042115/0140 →
SECURITY INTEREST Recorded Mar 10, 2017
From: ANGIOTECH PHARMACEUTICALS, INC.
To: VIRTUS GROUP, LP
Reel/Frame 041539/0864 →