Compounds and method for the inhibition of the expression of VCAM-1
View Patent ↗This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.
1. A compound of the formula
or a pharmaceutically acceptable salt or ester thereof.
2. A compound of the formula
or a pharmaceutically acceptable salt thereof.
3. A pharmaceutical composition comprising a compound of the formula
together with a pharmaceutically acceptable carrier.
4. The pharmaceutical composition of claim 3 , wherein the pharmaceutically acceptable carrier is suitable for oral administration.
5. The pharmaceutical composition of claim 3 , wherein the pharmaceutically acceptable carrier is suitable for topical administration.
6. The pharmaceutical composition of claim 3 , wherein the pharmaceutically acceptable carrier is suitable for intravenous administration.
7. The pharmaceutical composition of claim 3 , wherein the pharmaceutically acceptable carrier is suitable for subcutaneous administration.
8. The pharmaceutical composition of claim 3 , wherein the pharmaceutically acceptable carrier is suitable for intraperitoneal administration.
9. The pharmaceutical composition of claim 3 , wherein the pharmaceutically acceptable carrier is suitable for intramuscular administration.
10. The pharmaceutical composition of claim 3 , wherein the pharmaceutically acceptable carrier is suitable for submucosal administration.
11. The pharmaceutical composition of claim 3 , wherein the pharmaceutically acceptable carrier is suitable for inhalation administration.
12. The pharmaceutical composition of claim 3 , wherein the pharmaceutically acceptable carrier is suitable for transdermal administration.