IP Library › Granted Patent US 6,872,850
Granted Patent B2
US 6,872,850 · App. 10/117,955 · Granted Mar 29, 2005

Small molecule inhibitors of secretion of proteins encoded by ARE-mRNAs

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Quick Facts
Patent No.
US 6,872,850
App. No.
10/117,955
Granted
Mar 29, 2005
Kind
B2
Abstract

The invention features compounds that inhibit secretion of a protein encoded by an ARE-mRNA or that modulate regulation of an ARE-mRNA. These compounds are useful for the treatment or prevention of conditions involving proteins encoded by ARE-mRNAs, such as TNFα.

Claims (30)

1. A compound having one of the following formulas:

or a derivative or salt thereof, wherein

R 1 and R 6 are independently selected from the group consisting of an alkyl and an aryl group;

R 2 and R 5 are independently selected from the group consisting of hydrogen, an alkyl, and an aryl group;

R 3 and R 4 are independently selected from the group consisting of hydrogen and an alkyl group;

X is oxygen or H 2 N(HN)C(H)NN—; and

m is at least one;

or a derivative or salt or salt thereof, wherein

R 1 and R 6 are independently selected from the group consisting of an alkyl and an aryl group;

R 2 and R 5 are independently selected from the group consisting of hydrogen, an alkyl, and an aryl group;

R 3 and R 4 are independently selected from the group consisting of hydrogen and an alkyl; and

m is at least one;

or a derivative or salt or salt thereof, wherein

R 1 and R 5 are independently selected from the group consisting an aryl and an alkyl group;

R 2 is hydrogen, an alkyl, or aryl group;

R 3 and R 4 are independently selected from the group consisting of hydrogen and an alkyl group;

X is oxygen or H 2 N(HN)C(H)NN—; and

m is at least one;

or a derivative or salt or salt thereof, wherein

R 1 and R 6 are independently selected from the group consisting of an alkyl and an aryl group;

R 3 is hydrogen, an alkyl, or an aryl group;

R 2 , R 4 , and R 5 are independently selected from the group consisting of hydrogen and an alkyl; and

m is at least one.

2. The compound of claim 1 , wherein said compound is

3. The compound of claim 1 , wherein said compound is

4. The compound of claim 1 , wherein said compound is

5. The compound of claim 1 , wherein said compound is

6. The compound of claim 1 , wherein said compound is

7. The compound of claim 1 , wherein said compound is

8. The compound of claim 1 , wherein said compound is

Assignments (2)
CONVERTIBLE SECURED SUBORDINATED BRIDGE NOTE Recorded Jan 27, 2003
From: MESSAGE PHARMACEUTICALS, INC.
To: S. R. ONE, LIMITED
Reel/Frame 013699/0359 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 11, 2002
From: GIORDANO, ANTHONY; STURGESS, MICHAEL A.
To: MESSAGE PHARMACEUTICALS
Reel/Frame 012981/0055 →