Occlusive composition
View Patent ↗The present invention provides an occlusive composition comprising: a) a poly(2-cyanoacrylate) monomer of the following formula (I): wherein n≧2 and R is an organic moiety; and b) a visualization agent. The present invention also provides a method for creating a solid mass in an ionic fluid-containing bodily cavity within a living organism, comprising delivering into the bodily cavity a clinically sufficient amount of an occlusive composition comprising a poly(2-cyanoacrylate) monomer of formula (I) and a visualization agent.
1. An occlusive composition comprising: a) a poly(2-cyanoacrylate) monomer of the following formula (I):
wherein n≧2 and R is an organic moiety, and b) a visualization agent.
2. The occlusive composition of claim 1 , further comprising a mono(2-cyanoacrylate) monomer of the following formula (II):
wherein R′ is an organic moiety.
3. The occlusive composition of claim 1 , wherein n=2.
4. The occlusive composition of claim 1 , wherein n≧3.
5. The occlusive composition of claim 3 , wherein R is derived from a bis(hydroxylterminated) polymer, the polymer being selected from the group consisting of poly(ethylene glycol), poly(propylene glycol), poly(tetramethylene glycol), poly(isobutylene), poly(dimethyl siloxane), poly(propylene glycol-block-ethylene glycol-block-propylene glycol), poly(glycolic acid), poly(lactic acid), polycaprolactone, and copolymers thereof.
6. The occlusive composition of claim 2 , wherein the monomer of formula (II) comprises less than or equal to about 50% by weight of the total amount of the monomers of formulas (I) and (II) present in the occlusive composition.
7. The occlusive composition of claim 1 , wherein R has a molecular weight of at least about 200 g/mol.
8. The occlusive composition of claim 7 , wherein R has a molecular weight of at least about 400 g/mol.
9. The occlusive composition of claim 8 , wherein R has a molecular weight of at least about 600 g/mol.
10. The occlusive composition of claim 1 , wherein the visualization agent is one or more radiopaque functional groups covalently incorporated as part of the R group.
11. The occlusive composition of claim 1 , further comprising one or more additives selected from the group consisting of formaldehyde scavengers, polymerization inhibitors, plasticizers, rheology-modifying agents, liquid carriers, and bioactive agents.
12. The occlusive composition of claim 11 , wherein said one or more additives are selected from the group consisting of plasticizers and liquid carriers.
13. A method for creating a solid mass in an ionic fluid-containing bodily cavity within a living organism, comprising delivering into the bodily cavity a clinically sufficient amount of the occlusive composition of claim 1 .
14. The method of claim 13 , wherein the bodily cavity comprises at least one blood vessel, and the ionic fluid is blood.
15. The method of claim 13 , wherein the bodily cavity is an aneurysm, an arteriovenous malformation, a fistula, or the feeding artery of a tumor.
16. A method for tissue bulking in a living organism, comprising delivering into a tissue a clinically sufficient amount of the occlusive composition of claim 1 .
17. A method for the therapeutic treatment of a living organism, comprising delivering to a bodily cavity a clinically sufficient amount of the occlusive composition of claim 1 , wherein said composition further comprises a clinically sufficient amount of one or more bioactive agents.