Process to prepare 2-aminoindan derivatives
The present invention relates to (2S)-enantiomers of 2-aminoindan derivatives of formula I: and a novel process for the preparation of them.
1. A compound selected from the group consisting of
Where R is a C 1 -C 8 ALKYL.
2. A compound of claim 1 which is (1S,2S)-trans-(−)-2-amino-6-ethoxy-2,3-dihydro-1H-inden-1o or its chiral salt.
3. A compound of claim 1 which is (1S,2S)-trans-(−)-2-amino-6-ethoxy-2,3-dihydro-1H-inden-1o (R)-(−)-mandelate.
4. A compound of claim 1 which is (1S,2S)-trans-2-(dipropylamino)-6-ethoxy-2,3-dihydro-1H-inden-1-ol or a pharmaceutically acceptable salt thereof.
5. A compound of claim 1 which is (2S)-5-ethoxy-2,3-dihydro-N,N-dipropyl-1H-inden-2-amine or a pharmaceutically acceptable salt thereof.
6. A compound of claim 1 which is (R)-5-bromo-6-ethoxy-2,3-dihydro-N,N-dipropyl-1H-inden-2-amine or a pharmaceutically acceptable salt thereof.