Iodothyronine compositions
View Patent ↗The present invention relates to compositions comprising thyroxine (T4) and triiodothyronine (T3). More specifically, the invention relates to thyroxine (T4) and triiodothyronine (T3) compositions that include a peptide carrier and thyroxine (T4) and triiodothyronine (T3) covalently attached to at least one of the N-terminus, the C-terminus, a side chain of the peptide carrier, and/or interspersed within the peptide chain; methods for protecting and administering thyroxine (T4) and triiodothyronine (T3); and methods for treating thyroid disorders.
1. A composition comprising:
a single T3 conjugated to the N-terminus of a peptide carrier,
wherein said peptide carrier is fewer than 15 amino acids and consists essentially of the one or more of the 20 naturally occurring amino acids; and
wherein said composition is in a form suitable for oral administration and delivery of a pharmaceutically effective amount of T3.
2. The composition of claim 1 , comprising T3-Glu-Glu.
3. The composition of claim 1 , comprising T3-Ser-Ser.
4. The composition of claim 1 , comprising T3-PolySer.
5. The composition of claim 1 , comprising T3-Lys.
6. The composition of claim 1 , wherein said carrier peptide is an amino acid.
7. The composition of claim 1 , wherein said composition formulations afford sustained release of T3.
8. The composition of claim 1 , wherein said carrier peptide enhances absorption.
9. The composition of claim 1 , wherein said carrier peptide is a homopolymer.
10. The composition of claim 1 , wherein said carrier peptide is a heteropolymer.
11. The composition of claim 1 , which is formulated to enhance the solubility of the T3 in aqueous or organic solvents.
12. The composition of claim 11 , wherein said enhanced solubility allows even dispersion in polymer formulations.
13. A method of treating a thyroid hormone disorder comprising administering the composition of claim 1 .
14. The composition of claim 1 , wherein said form suitable for oral administration is a tablet, a capsule, a suspension, or a solution.
15. The composition of claim 1 , wherein said carrier peptide consists of one or more of the 20 naturally occurring amino acids.
16. A composition comprising a Glu-Glu carrier peptide that comprises at least one T3 active agent, with the proviso that no more than four T3 active agents are contiguously bonded.
17. T3-Glu-Glu.
18. A composition comprising T3-Glu-Glu.
19. The composition of claim 18 , wherein said T3-Glu-Glu is covalently attached to PEG.
20. The composition of claim 18 , wherein said T3-Glu-Glu is covalently attached to cyclodextrin.
21. The composition of claim 18 , wherein said T3-Glu-Glu is non-covalently attached to cyclodextrin.
22. A method of treating a thyroid hormone disorder comprising administering the composition of claim 15 .
23. A method of treating a thyroid hormone disorder comprising administering the composition of claim 16 .
24. A method of treating a thyroid hormone disorder comprising administering T3-Glu-Glu.
25. A method of treating a thyroid hormone disorder comprising administering the composition of claim 18 .