Hydrophilic coatings for medical implements
View Patent ↗Compositions, methods, devices and kits utilizing water-based hydrophilic coating formulations on medical implements. The composition for applying a coating comprises a sulfonated polyester, water, and a surface active agent. Methods for coating a medical implement comprise providing an aqueous dispersion comprising sulfonated polyester and surface active agent, contacting the medical implement with the aqueous dispersion, and drying the medical implement. Methods for acquiring a sample of bodily fluid from a patient comprise coating a needle with a sulfonated polyester, penetrating the needle into the patient, and drawing bodily fluid through the needle.
1. A method for forming a hydrophilic coating on a medical implement, comprising:
(a) providing an aqueous dispersion comprising sulfonated polyester and surface active agent;
(b) contacting said medical implement in said aqueous dispersion; and
(c) drying said medical implement.
2. The method of claim 1 wherein providing said aqueous dispersion of said sulfonated polyester and surface active agent comprises between approximately 0.5% and approximately 30% of sulfonated polyester by weight in water and between approximately 0.1% and approximately 5% of surface active agent by weight in water.
3. The method of claim 1 wherein said surface active agent comprises at least one surfactant from the group consisting of poly (oxyethylene-co-oxypropylene )block polymer, ethylene oxide-propylene oxide-ethylene oxide triblock copolymer, N-oleyl-N-methyl taurate, and di-isooctylsulphosuccinate.
4. The method of claim 1 wherein said contacting said medical implement in said aqueous dispersion comprises dipping said medical implement into said aqueous dispersion.
5. The method of claim 1 wherein said sulfonated polyester comprises a sulfonated poly(alkylene phthalate).
6. The method of claim 1 wherein said sulfonated polyester comprises a polymeric compound having the structure
where n is an integer having a value between 3 and 100,000.
7. The method of claim 1 wherein said sulfonated polyester comprises a sulfonated poly(ethylene isophthalate).
8. The method of claim 1 wherein said sulfonated polyester comprises poly(ethylene 4-sodiosulfenyl isophthalate).
9. The method of claim 1 wherein drying said medical implement comprises; heating the coated medical implement at approximately about 60° C. to about 120° C.
10. The method of claim 1 wherein said medical implement is a lancing implement.
11. The method of claim 1 wherein the medical implement is a microneedle.
12. A medical implement, comprising a needle having a coating thereon comprising a sulfonated polyester.
13. The medical implement of claim 12 , wherein said coating comprises of between approximately 80% and approximately 98% weight of said sulfonated polyester, and between approximately 20% and approximately 2% by weight of surface active agent.
14. The medical implement of claim 13 wherein said sulfonated polyester comprises a sulfonated poly(alkylene phthalate).
15. The medical implement of claim 14 wherein said sulfonated polyester comprises a sulfonated poly(ethylene isophthalate).
16. The medical implement of claim 15 wherein said sulfonated polyester comprises poly(ethylene 4-sodiosulfenyl isophthalate).
17. A kit for drawing a sample of a bodily fluid, comprising the medical implement of claim 13 , and a test strip configured to receive said sample of bodily fluid.