IP Library › Granted Patent US 7,115,408
Granted Patent B1
US 7,115,408 · App. 10/139,139 · Granted Oct 3, 2006

Method of stabilizing hyaluronidase with annexin II

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Quick Facts
Patent No.
US 7,115,408
App. No.
10/139,139
Granted
Oct 3, 2006
Kind
B1
Abstract

This invention relates generally to the use of annexin II for the purpose of stabilizing a hyaluronidase enzyme for administration to the eyes of humans or other mammals.

Claims (6)

1. A method of stabilizing a liquid composition comprising:

(a) identifying a liquid enzyme in need of stabilization, and

(b) adding annexin II to said liquid enzyme in need of stabilization, wherein said liquid enzyme is hyaluronidase.

2. A method of stabilizing a liquid composition comprising:

(a) adding annexin II to a liquid enzyme in need of stabilization, wherein said liquid enzyme is hyaluronidase, and

(b) measuring stabilization of said liquid enzyme.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Jun 8, 2012
From: SPROUT CAPITAL IX, L.P.; SPROUT ENTREPRENEURS' FUND, L.P.; DONALDSON, LUFKIN & JENRETTE SECURITIES CORPORATION, AS NOMINEE FOR DLJ FIRST ESC, L.P., EMA 2001 PLAN, L.P., CSFB 2001 INVESTORS, L.P., CREDIT SUISSE FIRST BOSTON PRIVATE EQUITY, INC., DOCKLANDS 2001 PLAN, L.P., PARADEPLATZ 2001 PLAN, L.P.; INVESTOR GROWTH CAPITAL LIMITED; INVESTOR GROUP L.P.; DIONIS TRUST; GRANT GUND 1978 TRUST; G. ZACHARY GUND 1978 TRUST; KBL HELATHCARE, LP; KBL PARTNERSHIP, LP; SANDERLING VENTURE PARTNERS V CO-INVESTMENT FUND, L.P.; SANDERLING V BIOMEDICAL CO-INVESTMENT FUND, L.P.; SANDERLING V LIMITED PARTNERSHIP; SANDERLING V BETEILIGUNGS GMBH & CO. KG
To: ISTA PHARMACEUTICALS, INC.
Reel/Frame 028347/0088 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 23, 2002
From: RICH, KATHRYN A.
To: ISTA PHARMACEUTICALS, INC.
Reel/Frame 013596/0321 →
SECURITY INTEREST Recorded Sep 25, 2002
From: ISTA PHARMACEUTIALS, INC.
To: SPROUT CAPITAL IX, L.P.; SPROUT ENTREPRENEURS' FUND, L.P.; DONALDSON, LUFKIN & JENRETTE SECURITIES CORPORATION, AAS NOMINEE FOR: DLJ FIRST ESC, L.P., EMA 2001 PLAN, L.P., CSFB 2001 INVESTORS, L.P. CREDIT SUISSE FIRST BOSTON RPIVATE EQUITY, INC., DOCKLANDS 2001 PLAN, L.P., PARADEPLATZ 2001 PLAN, L.P.; INVESTOR GROWTH CAPITAL LIMITED NATIONAL WESTMINSTER HOUSE; INVESTOR GROUP L.P. NATIONAL WESTMINSTER HOUSE; DIONIS TRUST; GRANT GUND 1978 TRUST; G. ZACHARY GUND 1978 TURST; KBL, HEALTHCARE, LP; KBL PARTNERSHIP, LP; SANDERLING VENTURE PARTNERS V CO.-INVESTMENT FUND, L.P.; SANDERLING V BIOMEDICAL CO-INVESTMENT FUND, L.P.; SANDERLING V. LIMITED PARTNERSHIP; SANDERLING V BETEILIGUNGS GMBH & CO. KG
Reel/Frame 013323/0586 →