Method of forming an aerosol for inhalation delivery
View Patent ↗The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10 μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.
1. A method of forming an aerosol for use in inhalation therapy comprising:
(a) heating a substrate coated with a composition comprising a drug for a period of time, thereby forming a vapor, wherein the period is less than 500 milliseconds and wherein the increase in temperature of the substrate over the period is greater than 1000° C./s; and
(b) allowing the vapor to cool, thereby forming an aerosol comprising the drug.
2. The method according to claim 1 , wherein the increase in temperature of the substrate over the period is greater than 2000° C./s.
3. The method according to claim 1 , wherein greater than 0.1 mg of the composition is vaporized in less than 100 milliseconds from the start of heating.
4. The method according to claim 1 , wherein the increase in temperature of the substrate over the period is greater than 5,000° C./s.
5. The method according to claim 4 , wherein greater than 0.25 mg of the composition is vaporized in less than 100 milliseconds from the start of heating.
6. The method according to claim 5 , wherein the increase in temperature of the substrate over the period is greater than 7,500° C./s.
7. A method of forming an aerosol for use in inhalation therapy comprising:
(a) heating a substrate coated with a composition comprising a drug to form a vapor in a period of time less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and
(b) allowing the vapor to cool, thereby forming an aerosol comprising the drug.
8. The method according to claim 7 , wherein the vapor has a mass greater than 0.25 mg.
9. The method according to claim 7 , wherein the vapor is formed in less than 75 milliseconds.
10. The method according to claim 8 , wherein the vapor has a mass greater than 0.5 mg.
11. The method according to claim 9 , wherein the period of time is less than 50 milliseconds.
12. The method according to claim 3 , wherein the formed aerosol is greater than 80 percent by weight of the drug.
13. The method according to claim 3 , wherein the formed aerosol contains less than 5 percent by weight of drug decomposition products.
14. The method according to claim 3 , wherein the formed aerosol is stable over 1 second.
15. The method according to claim 3 , wherein the formed aerosol has an MMAD in the 10 nm to 100 nm range.
16. The method according to claim 3 , wherein the formed aerosol has an MMAD in the 1 μm to 3 μm range.
17. The method according to claim 3 , wherein the geometric standard deviation of the form aerosol is other than 1.
18. The method according to claim 7 , wherein the formed aerosol is greater than 80 percent by weight of the drug.
19. The method according to claim 7 , wherein the formed aerosol contains less than 5 percent by weight of drug decomposition products.
20. The method according to claim 7 , wherein the formed aerosol is stable over 1 second.
21. The method according to claim 7 , wherein the formed aerosol has an MMAD in the 10 nm to 100 nm range.
22. The method according to claim 7 , wherein the formed aerosol has an MMAD in the 1 μm to 3 μm range.
23. The method according to claim 7 , wherein the geometric standard deviation of the form aerosol is other than 1.
24. The method according to claim 3 , wherein the film is less than 10 μm thick.
25. The method according to claim 24 , wherein the film is less than 5 μm thick.
26. The method according to claim 24 , wherein the film is between 10 nm and 5 μm thick.
27. The method according to claim 25 , wherein the film is less than 3 μm thick.
28. The method according to claim 26 , wherein the film is between 10 nm and 3 μm thick.
29. The method according to claim 7 , wherein the film is less than 10 μm thick.
30. The method according to claim 29 , wherein the film is less than 5 μm thick.
31. The method according to claim 29 , wherein the film is between 10 nm and 5 μm thick.
32. The method according to claim 30 , wherein the film is less than 3 μm thick.
33. The method according to claim 31 , wherein the film is between 10 nm and 3 μm thick.