Nucleic acid-based compounds and methods of use thereof
View Patent ↗The invention provides compounds capable of treating against hepatitis infections, particularly hepatitis B viral infections. Compounds of the invention are nucleic acid-based and preferably comprise 2, 3, 4, 5 or 6 nucleoside units.
1. A compound having the structure
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising the compound of claim 1 in combination with a pharmaceutically acceptable carrier.
3. The pharmaceutical composition of claim 2 wherein the pharmaceutically acceptable carrier comprises a lipid.
4. A pharmaceutical composition for treating viral infections comprising a therapeutically effective amount of a compound of claim 1 in combination with a pharmaceutically acceptable carrier.
5. A pharmaceutical composition for treating HBV infection comprising a therapeutically effective amount of a compound of claim 1 in combination with a pharmaceutically acceptable carrier.
6. A pharmaceutical composition for treating a viral infection comprising a therapeutically effective amount of a compound of claim 1 in combination with a therapeutically effective amount of a reverse transcriptase inhibitor and a pharmaceutically acceptable carrier.
7. A pharmaceutical composition of claim 6 wherein the reverse transcriptase inhibitor is 3TC.
8. A method for treating a subject who is suffering from or susceptible to an HBV infection, comprising administering to the subject an effective amount of a compound having the structure
or a pharmaceutically acceptable salt thereof.
9. The method of claim 8 wherein the subject is suffering from or susceptible to a drug resistant HBV infection.
10. The method of claim 8 wherein the subject is human.