Nucleic acids encoding the PRO1561 polypeptide

1. An isolated nucleic acid having at least 95% nucleic acid sequence identity to:

(a) a fragment of the nucleic acid sequence shown in FIG. 533 (SEQ ID NO:533), wherein the fragment encodes the polypeptide shown in FIG. 534 (SEQ ID NO:534), lacking amino acids 1–17;

(b) the nucleic acid sequence shown in FIG. 533 (SEQ ID NO:533);

(c) the full-length coding sequence of the nucleic acid sequence shown in FIG. 533 (SEQ ID NO:533); or

(d) the full-length coding sequence of the cDNA deposited under ATCC accession number 203313;

wherein the isolated nucleic acid encodes a polypeptide that has phospholipase activity.

2. The isolated nucleic acid of claim 1 having at least 99% nucleic acid sequence identity to:

(a) a fragment of the nucleic acid sequence shown in FIG. 533 (SEQ ID NO:533), wherein the fragment encodes the polypeptide shown in FIG. 534 (SEQ ID NO:534), lacking amino acids 1–17;

(b) the nucleic acid sequence shown in FIG. 533 (SEQ ID NO:533);

(c) the full-length coding sequence of the nucleic acid sequence shown in FIG. 533 (SEQ ID NO:533); or

(d) the full-length coding sequence of the cDNA deposited under ATCC accession number 203313;

wherein the isolated nucleic acid encodes a polypeptide that has phospholipase activity.

3. An isolated nucleic acid comprising:

(a) a nucleic acid sequence encoding the polypeptide shown in FIG. 534 (SEQ ID NO:534);

(b) a nucleic acid sequence encoding the polypeptide shown in FIG. 534 (SEQ ID NO:534), lacking amino acids 1–17;

(c) the nucleic acid sequence shown in FIG. 533 (SEQ ID NO:533);

(d) the full-length coding sequence of the nucleic acid sequence shown in FIG. 533 (SEQ ID NO:533); or

(e) the full-length coding sequence of the cDNA deposited under ATCC accession number 203313.

4. The isolated nucleic acid of claim 3 comprising a nucleic acid sequence encoding the polypeptide shown in FIG. 534 (SEQ ID NO:534).

5. The isolated nucleic acid of claim 3 comprising a nucleic acid sequence encoding the polypeptide shown in FIG. 534 (SEQ ID NO:534), lacking amino acids 1–17.

6. The isolated nucleic acid of claim 3 comprising the nucleic acid sequence shown in FIG. 533 (SEQ ID NO:533).

7. The isolated nucleic acid of claim 3 comprising the full-length coding sequence of the nucleic acid sequence shown in FIG. 533 (SEQ ID NO:533).

8. The isolated nucleic acid of claim 3 comprising the full-length coding sequence of the cDNA deposited under ATCC accession number 203313.

9. An isolated nucleic acid that hybridizes to the complement of:

(a) a nucleic acid sequence encoding the polypeptide shown in FIG. 534 (SEQ ID NO:534);

(b) a nucleic acid sequence encoding the polypeptide shown in FIG. 534 (SEQ ID NO:534), lacking amino acids 1–17;

(c) the nucleic acid sequence shown in FIG. 533 (SEQ ID NO:533);

(d) the full-length coding sequence of the nucleic acid sequence shown in FIG. 533 (SEQ ID NO:533); or

(e) the full-length coding sequence of the cDNA deposited under ATCC accession number 203313;

wherein the isolated nucleic acid encodes a polypeptide that has phospholipase activity and hybridizes under the stringent conditions of 50% formamide, 5×SSC (0.75 M NaCl, 0.075 M sodium citrate), 50 mM sodium phosphate (pH 6.8), 0.1% sodium pyrophosphate, 5× Denhardt's solution, sonicated salmon sperm DNA (50 μg/ml), 0.1% SDS, and 10% dextran sulfate at 42° C., with washes at 42° C. in 0.2×SSC (sodium chloride/sodium citrate) followed by a high-stringency wash consisting of 0.1×SSC containing EDTA at 55° C.

10. A vector comprising the nucleic acid of claim 1 .

11. The vector of claim 10 , wherein said nucleic acid is operably linked to control sequences recognized by an isolated host cell transformed with the vector.

12. An isolated host cell comprising the vector of claim 10 .

13. The host cell of claim 12 , wherein said cell is a CHO cell, an E. coli or a yeast cell.

14. The isolated polynucleotide of claim 9 , wherein the isolated polynucleotide encodes a polypeptide of at least 80 amino acids in length.