Biochemical analysis unit and method of producing thereof
View Patent ↗The biochemical analysis unit has a base plate and absorptive regions. The absorptive regions are surrounded by the base plate formed of materials which shield a radioactive ray and a light. In the absorptive regions are applied and absorbed specific binding substances to be bound with substances derived from a living organism that are labeled with labeling substances for generating the radioactive ray or the light. The base plate prevents the specific binding substances from penetrating in the other absorptive regions. When an analysis of data of the radioactive ray and the light is carried out, an image of the radioactive ray and the light is generated without noises.
1. A biochemical analysis unit used for analyzing a data of a radioactive ray and a light, comprising:
a plate member formed of a shielding material which can shield at least one of said radioactive ray and said light, said plate member having a first surface and a second surface;
plural through-holes formed in said plate member;
an absorptive membrane formed of an absorptive material, covering said first surface of said plate member, a part of said absorptive membrane provided in said plural through-holes;
absorptive regions formed of through said through-holes of in said second surface of said plate member;
wherein the absorptive membrane is provided to fill more than half of the volume of each of the plural through-holes.
2. A biochemical analysis unit as described in claim 1 , wherein in said absorptive regions are absorbed specific binding substances which specifically binds with substances derived from living organism that are labeled by at least one of labeling substances including radioactive labeling substances, fluorescent substances and chemiluminescent labeling substances.
3. A biochemical analysis unit as described in claim 2 , wherein said specific binding substances and said substances derived from living organism are bound through one of hybridization, antigen-antibody reaction and receptor-ligand.
4. A biochemical analysis unit as described in claim 1 , wherein said plate member is fixed to said absorptive membrane through an adhesive agent.
5. A biochemical analysis unit as described in claim 3 , wherein said plate member decreases a density of said radioactive ray and the light less than 1/5 when said radioactive ray and the light passes in said plate member at a length corresponding to a distance between the nearest two of said through-holes.
6. A biochemical analysis unit as described in claim 5 , wherein said plate member decreases a density of said radioactive ray and the light less than 1/10 when said radioactive ray and the light passes in said plate member at a length corresponding to a distance between the nearest two of said through-holes.
7. A biochemical analysis unit as described in claim 6 wherein said plate member is formed of at least one of metallic materials, ceramic materials and plastic materials.
8. A biochemical analysis unit as described in claim 7 , wherein said plate member is formed of said plastic materials containing particles of oxides of metals.
9. A biochemical analysis unit as described in claims 8 , wherein said absorptive regions and said plate member form a flat surface.
10. A biochemical analysis unit as described in claim 8 , wherein said absorptive regions are retracted from a face of said plate member.
11. A biochemical analysis unit as described in claim 3 , wherein the number of said absorptive regions is more than 10.
12. A biochemical analysis unit as described in claim 11 , wherein the number of said absorptive regions is more than 1000.
13. A biochemical analysis unit as described in claim 12 , wherein the number of said absorptive regions is more than 10000.
14. A biochemical analysis unit as described in claim 3 , wherein each of said absorptive regions has a size less than 5 mm 2 .
15. A biochemical analysis unit as described in claim 14 , wherein each of said absorptive regions has a size less than 1 mm 2 .
16. A biochemical analysis unit as described in claim 15 , wherein each of said absorptive regions has a size less than 0.1 mm 2 .
17. A biochemical analysis unit as described in claim 3 , wherein the averaged density of the number of said absorptive regions is more than 10/cm 2 .
18. A biochemical analysis unit as described in claim 17 , wherein the averaged density of the number of said absorptive regions is more than 1000/cm 2 .
19. A biochemical analysis unit as described in claim 18 , wherein the averaged density of the number of said absorptive regions is more than 10000/cm 2 .
20. A biochemical analysis unit as described in claim 3 , wherein said plural absorptive regions are arranged in a pattern.
21. A biochemical analysis unit as described in claim 3 , wherein said absorptive material is a porous material.
22. A biochemical analysis unit as described in claim 21 , wherein said porous material is a carbon porous material or may be used for membrane filter.
23. A biochemical analysis unit as described in claim 3 , wherein said absorptive material contains a fiber material.