Compositions comprising
View Patent ↗International patent application WO99/61053 discloses immunogenic compositions that comprise N. meningitidis serogroup C oligosaccharide conjugated to a carrier, in combination with N. meningitidis serogroup B outer membrane protein. These are disclosed in the present application in combination with further Neisserial proteins and/or protective antigens against other pathogenic organisms (e.g. Haemophilus influenzae , DTP, HBV, etc.).
1. A composition comprising (a) Neisseria meningitidis C (NmC) oligosaccharide conjugated to a carrier protein, (b) Neisseria meningitidis B (NmB) outer membrane protein, and (c) an isolated polypeptide comprising an amino acid sequence having 80% or greater sequence identity to SEQ ID NO: 601, wherein the components (a), (b) and (c) were mixed together and wherein the composition comprises a carrier-adjuvant selected from aluminum hydroxide, aluminum phosphate, and an oil-in-water emulsion.
2. The composition of claim 1 further comprising (d) a protective saccharide antigen against Neisseria meningitidis serogroup A.
3. The composition of claim 1 further comprising (d) a protective saccharide antigen against Neisseria meningitidis serogroup W.
4. The composition of claim 1 further comprising (d) a protective saccharide antigen against Neisseria meningitidis serogroup Y.
5. The composition according to claim 1 , wherein the NmB outer membrane protein is present as proteoliposomic vesicles.
6. The composition of claim 1 , wherein the carrier protein is CRM197.
7. A composition comprising (a) Neisseria meningitidis C (NmC) oligosaccharide conjugated to a carrier protein, (b) Neisseria meningitidis B (NmB) outer membrane protein, and (c) a polypeptide comprising an amino acid sequence having 80% or greater sequence identity to SEQ ID NO: 601, wherein the components (a), (b) and (c) were mixed together and the carrier protein is a non-toxic diphtheria toxin.