Macrocyclic compounds and their use
View Patent ↗The subject invention pertains to macrocyclic compounds, and their use, the compounds having the formula (I) wherein X is a ring bearing an optionally-protected functional group or solid phase group R 1 , Y is a linker optionally bearing an optionally-protected functional group or solid phase group R 2 , m is at least 3, and each instance of X, Y, R 1 and R 2 may be the same or different.
1. A macrocyclic compound of the formula
wherein X is a triazine ring bearing an optionally-protected functional group or solid phase R 1 ; Y is a linker optionally bearing an optionally-protected functional group or solid phase R 2 ; m is at least 3, and each instance of Y, R 1 and R 2 may be the same or different.
2. The compound according to claim 1 , wherein m is 3.
3. The compound according to claim 1 , wherein Y includes a piperazine or xylene ring.
4. The compound according to claim 2 , wherein Y includes a piperazine or xylene ring.
5. The compound according to claim 1 , wherein R 1 or R 2 is a solid phase.
6. The compound according to claim 1 , wherein R 1 is an optionally protected functional group.
7. A method for the capture of a target solute in a solution, comprising contacting the solution with a compound of claim 1 , wherein R 1 and R 2 of said compound have affinity for the target solute.
8. A method for affinity binding of a target molecule, comprising contacting the target molecule with a compound of claim 1 , wherein R 1 and R 2 of said compound have affinity for the target molecule.