Local anesthetic methods and kits
Methods of reversing local anesthesia are disclosed. The methods comprise administering a local anesthetic and alpha adrenergic receptor agonist to induce local anesthesia followed by reversing anesthesia with a low dose of an alpha adrenergic receptor antagonist. Also disclosed are kits comprising a local anesthetic, an alpha adrenergic receptor agonist and a low dose of an alpha adrenergic receptor antagonist.
1. A solution comprising phentolamine mesylate at a concentration of from about 0.001 mg/ml to about 0.25 mg/ml, wherein said solution is effective to reverse anesthesia in an animal caused by previous administration of an anesthetic agent and an alpha adrenergic receptor agonist, said solution being present in a container that fits into a standard dental local anesthetic syringe.
2. The solution of claim 1 , wherein said phentolamine mesylate is present at a concentration of from about 0.05 mg/ml to about 0.1 mg/ml.
3. The solution of claim 1 , wherein said container comprises a dose of phentolamine mesylate at or below about 0.25 mg.
4. The solution of claim 3 , wherein said dose is at or below about 0.1 mg.
5. The solution of claim 4 , wherein said dose is about 0.08 mg.
6. The solution of claim 4 , wherein said dose is about 0.032 mg.
7. The solution of claim 1 , wherein said container is a CARPULE.
8. The solution of claim 1 , wherein said container has a volume of between 1.6 and 1.8 ml.
9. The solution of claim 1 , wherein said phentolamine mesylate is at a concentration of about 0.05 mg/ml to about 0.25 mg/ml.
10. The solution of claim 1 , wherein said phentolamine mesylate is at a concentration of about 0.25 mg/ml.
11. The solution of claim 1 , wherein said container comprises a dose of phentolamine mesylate of between about 0.0018 mg to about 0.45 mg.
12. The solution of claim 1 , wherein said dose is between about 0.09 mg to about 0.45 mg.