Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
View Patent ↗The present invention comprises a method of treating a sphincter that provides a sphincter electropotential mapping device with at least one of a mapping electrode or a treatment electrode. The sphincter electropotential mapping device is introduced into at least a portion of the sphincter, the lower esophageal sphincter, stomach, the cardia or the fundus. Bioelectric activity causing a relaxation of the sphincter is detected and energy is delivered from either the mapping electrode or the treatment electrode to treat the bioelectric activity. In another embodiment of the method of the invention, a method of treating a sphincter that provides a sphincter electropotential mapping device with at least one of a mapping electrode or a treatment electrode. The sphincter electropotential mapping device is introduced into at least a portion of the sphincter, the lower esophageal sphincter, stomach, the cardia or the fundus. The sphincter, lower esophageal sphincter, stomach, cardia or fundus is stimulated to produce a transient relaxation of the sphincter. The portion of the sphincter, lower esophageal sphincter, stomach, cardia or fundus causing a relaxation of the sphincter is indentified. Energy is delivered from the sphincter electropotential mapping device to treat the portion the sphincter, lower esophageal sphincter, stomach, cardia or fundus causing the transient relaxation of the sphincter.
1. An apparatus, comprising
a treatment device including at least one of a mapping electrode or a treatment electrode,
the treatment device being sized and configured for introduction into at least a portion of a tissue region comprising at least one of a sphincter, a lower esophageal sphincter, a stomach, a cardia or a fundus;
means for stimulating the tissue region to produce a transient relaxation of at least a portion of one of the sphincter, the lower esophageal sphincter, the stomach, the cardia or the fundus;
means coupled to the treatment device for identifying a portion of one of the sphincter, the lower esophageal sphincter, the stomach, the cardia or the fundus causing the transient relaxation; and
means coupled to the treatment device for delivering energy from the the mapping electrod or the treatment electrode to treat the portion of one the sphincter, the lower esophageal sphincter, the stomach, the cardia or the fundus causing the transient relaxation.
2. The apparatus of claim 1 ,
wherein the means for stimulating includes one of an electrical stimulation, a mechanical stimulation, a stretch stimulation or a chemical stimulation.
3. The apparatus of claim 1 , further comprising
means for performing a post treatment stimulation on one of the sphincter, the lower esophageal sphincter, the stomach, the cardia or the fundus; and
means for assessing an effectiveness of treatment in preventing the transient relaxation.
4. The apparatus of claim 1 ,
wherein the means for stimulating includes one of an external stimulation device or an internal stimulation device, wherein the external stimulation device is positionable on the skin near the stomach or wherein the internal stimulation device is positionable in the portion of one the sphincter, the lower esophageal sphincter, the stomach, the cardia or the fundus.
5. The apparatus of claim 4
wherein the means stimulating includes one of an internal stimulation or a transdermal stimulation.
6. An apparatus comprising
a treatment device having at least one of a mapping electrode or a treatment electrode,
the treatment device being sized and configured for introduction into at least a portion of a tissue region comprising at least one of a sphincter, a lower esophageal sphincter, a stomach, a cardia or a fundus;
means coupled to the treatment device for detecting an electrical activity causing a transient relaxation of at least a portion of the sphincter, the lower esophageal sphincter, the stomach, the cardia or the fundus;
means coupled to the treatment device for delivering energy to treat the electrical activity; and
means coupled to the treatment device for mapping the tissue region after the treatment to assess the effectiveness of the treatment.
7. An apparatus for comprising
a treatment device having at least one of a mapping electrode or a treatment electrode, the treatment device being sized and configured for introduction into at least a portion of one of sphincter, a lower esophageal sphincter, a stomach, a cardia or a fundus;
means for detecting a bioelectric activity causing a transient relaxation of at least a portion of the sphincter, the stomach, the cardia or the fundus; and
means for delivering energy from the treatment delivery device to treat the bioelectric activity;
the treatment device comprising
a basket assembly including a first and a second arm, the basket assembly being coupled to an elongated member and having a deployed and a non-deployed configuration;
an inflatable member coupled to the elongated member and positioned in an interior of the basket assembly, the inflatable member being coupled to an inflation lumen, the inflatable member having a deployed stare and a non-deployed state, wherein in the deployed state the inflatable member expands the basket assembly to the basket assembly deployed configuration;
a first energy delivery device positionable in the first arm and advanceable from the first arm to a selected treatment site; and
a second energy delivery device positionable in the second arm and advanceable from the second arm to a selected treatment site;
at least one of the first and second energy delivery device adapted being to adapted to deliver RF energy to a treatment site in one of the sphincter, the lower esophageal sphincter, the stomach, the cardia or the fundus to at least partially ablate one of a nerve pathway, an afferent pathway, a electrical pathway, a mechanoreceptor pathway or a chemoreceptor pathway.