IP Library › Granted Patent US 7,101,995
Granted Patent B2
US 7,101,995 · App. 10/157,674 · Granted Sep 5, 2006

Compositions and processes using siRNA, amphipathic compounds and polycations

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Quick Facts
Patent No.
US 7,101,995
App. No.
10/157,674
Granted
Sep 5, 2006
Kind
B2
Abstract

Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.

Claims (5)

1. A deliverable composition comprising: an amphipathic compound, a ethoxylated polyethyleneimine, and a siRNA.

2. The composition of claim 1 wherein the amphipathic compound has the structure comprising:

wherein R1 and R2 are selected from the group consisting of a C6–C24 alkene.

3. The amphipathic compound of claim 2 wherein R1 and R2 are the same.

4. The amphipathic compound of claim 2 wherein R1 and R2 are different.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 23, 2006
From: WOLFF, JON A.; HAGSTROM, JAMES E.; LEWIS, DAVID L.; HERWEIJER, HANS; LOOMIS, AARON G.; MONAHAN, SEAN D.
To: MIRUS BIO CORPORATION
Reel/Frame 017672/0136 →