IP Library › Granted Patent US 6,863,899
Granted Patent B2
US 6,863,899 · App. 10/165,629 · Granted Mar 8, 2005

Composite shaped bodies and methods for their production and use

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Quick Facts
Patent No.
US 6,863,899
App. No.
10/165,629
Granted
Mar 8, 2005
Kind
B2
Abstract

Shaped, composite bodies are provided. One portion of the shaped bodies comprises an RPR-derived porous inorganic material, preferably a calcium phosphate. Another portion of the composite bodies is a different solid material, preferably metal, glass, ceramic or polymeric. The shaped bodies are especially suitable for orthopaedic and other surgical use.

Claims (23)

1. A shaped body comprising:

a first segment comprising a polymerizable matrix and an inorganic filler; and in contact with at least a portion of the first segment, a second segment comprising calcium phosphate having substantially uniform macro-, meso- and microporosity together with a pore volume of at least about 30%. phosphate.

2. The shaped body of claim 1 wherein the pore volume of the inorganic material is at least about 50%.

3. The shaped body of claim 1 wherein the pore volume of the inorgaric material is at least about 70%.

4. The shaped body of claim 1 wherein the pore volume of the inorganic material is at least about 90%.

5. A composite body having at least two portions:

a first portion comprising the oxidation-reaction product of a blend comprising

at least one metal cation;

at least one oxidizing agent; and

at least one precursor anion oxidizable by said oxidizing agent to form an oxoanion;

the second portion being imbibed into the first portion wherein the second portion is selected from the group consisting of polycaprolactones, polyglycolic acid, poly-L-lactic acid, polysulfones, polyolefins, polyvinyl alcohol, polyalkenoics, polyacrylic acids, and polyesters.

6. The composite body of claim 5 wherein the second portion is polymerized.

7. A composite body for drug delivery comprising:

a first portion comprising the oxidation-reaction product of a blend comprising

at least one metal cation;

at least one oxidizing agent; and

at least one precursor anion oxidizable by said oxidizing agent to form an oxoanion;

a second, resorbable portion imbibed into the first portion; and

a medicament, medicament is a growth hormone, antibiotic material, proteins, cell signaling material, steroids, analgesics, or fertility drugs.

8. The composite shaped body of claim 7 wherein the medicament is absorbed into the solid composite body.

9. A shaped body comprising:

a first portion comprised of an inorganic material having substantially uniform macro-, meso- and microporosity together with a pore volume of at least about 30%; and

a second portion that contacts at least a portion of the first portion, wherein the second portion is a powder comprises L-Iactic acids comprised of a powder.